Novel bzd Fluorazepam is NOT simply the fluoro version of Alp(chloro), like Bromazolam was the bromo.

triazophile

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Aug 12, 2024
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The name led me to assume so and might confuse others. I have just learned about this new RC available, and a quick search shows it has a very close ancient Rx med "Loprazolam", related to Midazolam in structure and metabolism. It is flunitrazolam with some stuff attached to it, lowering potency and increasing duration. It should be very potent and active under 1mg, and has an active metabolite with the same half-life. That half-life should be several times longer than loprazolam (which is clonazolam with some other stuff attached).

Not one for me at all, but cool to see some different types of RC's vs something like ethylbromazolam.


Stay safe, readers
 
It is a brilliant choice that shows LF and BJC understand QSAR relationships well,

Loprazolam is an Rx counterpart, expect slightly lower potency by weight, heavier hypnotic effects and much greater duration.
 
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  9. O @ ochemdim: @necromedic ah ok interesting! Let me know what the researchers find out. The hypothesis makes sense, only thing I’d be wary of is the irritability of VG, and keep in mind, when VG and HCł are mixed, chlorôhýdrín is produced which is very irritating but that’d have to be pretty strong HÇł I believe and just washing before hand will rid the excess HÇł
  10. N @ necromedic: @ochemdim : anecdotally, especially with the way other people have prepared them with just distilled H2O and maybe EtOH or BA for sterility, I would definitely agree, and I’ve wondered if that it’s due to the speed of drainage with such a low weight solvent. That’s why I’ve experimented with adding VG to increase viscosity to let it hang in the NM a little longer. Possibly more diffusion/osmotic pressure with a dry vs hydrated medium?
  11. O @ ochemdim: @Royboy88, @Layne_Cobain, @necromedic in a couple research papers I’ve read, they always found that the sprays had lower absorption rates compared to traditional. I could be wrong but I’d research it if I were doing a study and needed references
  12. L @ Layne_Cobain: @Royboy99 never got to try one of those saline sprays but a snuff bullet is a great compromise love mine Amazon has good ones for cheap
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