- Joined
- Jun 30, 2019
- Messages
- 524
2-METHYL-AP-237 is an opioid analgesic drug that was widely used in China to treat pain in cancer patients as of 1986.It is one of the most potent compound among a series of analgesic acyl piperazines compounds first synthesized and reported in Japan in the 1970s.
2-METHYL-AP-237 has analgesic potency comparable to that of morphine but with a relatively higher therapeutic index.
The drug were initially claimed to be a non-narcotic analgesic. However, subsequent studies have shown 2-METHYL-AP-237 and similar acyl piperazines to be potent and selective agonists of μ-opioid receptor (MOR) with relatively low affinity for the δ-opioid receptor and the κ-opioid receptor. In accordance with these studies, results from the intravenous self-administration experiments in rats showed that 2-METHYL-AP-237 has a marked reinforcing effect with tolerance and dependence quickly developing. In addition, the morphine antagonist naloxone reverses the effect of AP-237 and precipitates withdrawal symptoms in 2-METHYL-AP-237 treated rats further indicating a mechanism of analgesia mediated via selective agonist activity at μ-opioid receptors.
here is a review that a guy in TN reported for your reference:
It is less caustic than 237 (even though 237 is only the tiniest bit caustic), but I can take more AMKD than I do 237, yet it still feels not as strong as the 237. Even at 80mg.
Also, the duration is definitely shorter. The comedown was harsher too, felt shitty man.
As for safety, I took a lot, with practically 0 side effects.
I would say 237 beats both AMKD & ODSMT
BUY
BUT*
If youbare interested in euphoria, it is:
237>AKMD>ODSMT
If youbare interested in duration with slight euphoria: 237> ODSMT>AKMD
they are all quite safe
Surprisingly safe
Well actually, ODSMT beats 237 slightly in duration, but 237 is so much better in every other area it still wins.
2-METHYL-AP-237 has analgesic potency comparable to that of morphine but with a relatively higher therapeutic index.
The drug were initially claimed to be a non-narcotic analgesic. However, subsequent studies have shown 2-METHYL-AP-237 and similar acyl piperazines to be potent and selective agonists of μ-opioid receptor (MOR) with relatively low affinity for the δ-opioid receptor and the κ-opioid receptor. In accordance with these studies, results from the intravenous self-administration experiments in rats showed that 2-METHYL-AP-237 has a marked reinforcing effect with tolerance and dependence quickly developing. In addition, the morphine antagonist naloxone reverses the effect of AP-237 and precipitates withdrawal symptoms in 2-METHYL-AP-237 treated rats further indicating a mechanism of analgesia mediated via selective agonist activity at μ-opioid receptors.
here is a review that a guy in TN reported for your reference:
It is less caustic than 237 (even though 237 is only the tiniest bit caustic), but I can take more AMKD than I do 237, yet it still feels not as strong as the 237. Even at 80mg.
Also, the duration is definitely shorter. The comedown was harsher too, felt shitty man.
As for safety, I took a lot, with practically 0 side effects.
I would say 237 beats both AMKD & ODSMT
BUY
BUT*
If youbare interested in euphoria, it is:
237>AKMD>ODSMT
If youbare interested in duration with slight euphoria: 237> ODSMT>AKMD
they are all quite safe
Surprisingly safe
Well actually, ODSMT beats 237 slightly in duration, but 237 is so much better in every other area it still wins.
not as rare as what u thought but hey pretty dang sought after pre covid
