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- May 2, 2021
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how to use an extract from the brains of pigs to rehabilitate your brain, reduce anxiety and depression, reduce withdrawals from drugs, delay tolerance development from drugs, protect yourself from neurodegenerative disease, and more:
Consequently, I’ve devoted a lot of time in the last two years to the study of neurogenesis – the reason I have a long series on serotonin.
Cerebrolysin is one of the only commercially available formulation of actual neurotrophic molecules. When I discovered it, I experimented with it so extensively that I think I may be the single human who has most used Cerebrolysin.
What is Cerebrolysin?
In 1949, Gerhart Harrer discovered that enzymatic hydrolysis of brain tissues produced a substance that stimulates nerve cells. It was subsequently registered as a drug in Austria by 1954, known as FPF1070, and has since become a commonly used medicine in East Asia and Eastern Europe, though it has yet to gain popularity in North America and Western Europe.
Cerebrolysin is a protein-based mixture of free amino acids (20%) and active, low molecular weight amino acid sequences (80%) that include the brain growth factors brain-derived neurotrophic factor (BDNF), glial cell-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and ciliary neurotrophic factor (CNF).
1. Endogenous growth factors:
a. Cerebrolysin administration upregulates nerve growth factor, brain derived neurotrophic factor and IGF-1
2. Oxidative stress and inflammation:
a. Cerebrolysin administration consistently reduces markers of inflammatory cytokines (e.g. TNF-a), reduces markers of oxidative stress, increases glutathione activity, and consequently protects neurons from apoptosis
3. GSK-3B:
a. Like donepezil, Cerebrolysin has been shown to inhibit glycogen synthase kinase-3-beta (GSK-3B
b. Inhibition of GSK-3B and cyclin-dependent kinase 5 (CDK5) activity are the reasons Cerebrolysin decreases beta amyloid deposition and microtubule-associated protein tau phosphorylation
4. Plastic changes:
a. Cerebrolysin induces plastic changes to dendritic morphology. Chronic Cerebrolysin exposure in aging rodents increases dendritic spine density and dendritic length in pyramidal neurons of the PFC and granule cells of the dentate gyrus.
b. Cerebrolysin reverses endothelial permeability dysfunction by reducing proinflammatory and pro-coagulation proteins and by increasing tight junction proteins.
Consequently, I’ve devoted a lot of time in the last two years to the study of neurogenesis – the reason I have a long series on serotonin.
Cerebrolysin is one of the only commercially available formulation of actual neurotrophic molecules. When I discovered it, I experimented with it so extensively that I think I may be the single human who has most used Cerebrolysin.
What is Cerebrolysin?
In 1949, Gerhart Harrer discovered that enzymatic hydrolysis of brain tissues produced a substance that stimulates nerve cells. It was subsequently registered as a drug in Austria by 1954, known as FPF1070, and has since become a commonly used medicine in East Asia and Eastern Europe, though it has yet to gain popularity in North America and Western Europe.
Cerebrolysin is a protein-based mixture of free amino acids (20%) and active, low molecular weight amino acid sequences (80%) that include the brain growth factors brain-derived neurotrophic factor (BDNF), glial cell-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and ciliary neurotrophic factor (CNF).
1. Endogenous growth factors:
a. Cerebrolysin administration upregulates nerve growth factor, brain derived neurotrophic factor and IGF-1
2. Oxidative stress and inflammation:
a. Cerebrolysin administration consistently reduces markers of inflammatory cytokines (e.g. TNF-a), reduces markers of oxidative stress, increases glutathione activity, and consequently protects neurons from apoptosis
3. GSK-3B:
a. Like donepezil, Cerebrolysin has been shown to inhibit glycogen synthase kinase-3-beta (GSK-3B
b. Inhibition of GSK-3B and cyclin-dependent kinase 5 (CDK5) activity are the reasons Cerebrolysin decreases beta amyloid deposition and microtubule-associated protein tau phosphorylation
4. Plastic changes:
a. Cerebrolysin induces plastic changes to dendritic morphology. Chronic Cerebrolysin exposure in aging rodents increases dendritic spine density and dendritic length in pyramidal neurons of the PFC and granule cells of the dentate gyrus.
b. Cerebrolysin reverses endothelial permeability dysfunction by reducing proinflammatory and pro-coagulation proteins and by increasing tight junction proteins.
