Do anti depressants dull down a euphoric drug high?

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questionsguy

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I realise this question is very broad/vague, but would taking an SSRI type of anti depressant dull down a drug high from opioids for example due to the nature of their functionality?

 
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questionsguy said:
I realise this question is very broad/vague, but would taking an SSRI type of anti depressant dull down a drug high from opioids for example due to the nature of their functionality?
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This is an awesome topic that I have been wondering about for years, to the point I will share some information that I have found related later tonight.  I feel almost with great certainty that they do “dull down” MY euphoric feeling from opioids.  I take Lexapro combined with Rexulti (an add on antidepressant) and almost immediately I began to feel it did reduce my typical type of opioid euphoria.   Again great topic…I hope others as well can give some good insight on this topic.

 
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This a the little bit I do know as to why they truly MAY dampen the euphoric effects from some of the common opioids, but not all.  Anyone who understands this very well please feel free to correct me or expand upon. Opioids come in two variations, those that act directly and those that have to be chemically processed by the body before they can begin to relieve pain and/or produce euphoric effects.  Direct-acting opioids, like morphine and oxycodone, can get right to work.  The other kind are called "prodrugs" like hydrocodone for example. Prodrugs need to be metabolized in the liver before they're able to bind with pain and/or pleasure receptors in the brain. 

Various antidepressants, definitely not all, but especially many SSRI’s , like Paxil, Prozac, Wellbutrin, or Zoloft, inhibit the activity of an enzyme in the liver, that metabolizes prodrug opioids. If the enzyme can't do its job, then the opioid can't either, or at the very least not as well. Supposedly if you take this type of problematic SSRI you are better off taking something like morphine or oxycodone instead, because they are what they call direct-acting drugs which don't need to be broken down by the liver.  Hope this was helpful.
 

Bottom line is they dampen the effects for me personally for sure.

 
 
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  4. drjimmy1964 @ drjimmy1964: Sweet Ol' Me asked about Real ID, Stoup. Are you responsive to emails ? LMAO
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  6. drjimmy1964 @ drjimmy1964: @bigblueallda You win. I am lost. Thought you were surprised your license was a Real ID, now you say you provided those items.
  7. drjimmy1964 @ drjimmy1964: @bigblueallda I was under the impression that you'd need all of the points to get a real ID . I'd check it's validity if you're gonna fly domestic any time soon, just to make sure. Not to tell you what to do, sorry -
  8. B @ bigblueallda: @drjimmy1964 In my state to get a Real ID, I need SS card, Birth Certificate and two proofs of residency. Which I am positive I had to provide to get a new ID when it had been expired.
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  10. B @ bigblueallda: I haven't flown in an airplane in 20 years lol. Can't recall the last government building I have been in either. According to the symbol it tells me I should have on my ID to make it a Real ID I do have one in my state
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  12. drjimmy1964 @ drjimmy1964: @Turbo259 advertising - putting in writing for example an negative action to show they are guilty prior to taking action.
  13. drjimmy1964 @ drjimmy1964: @bigblueallda are you sure you have a Real ID ? I mean , they really want 6 points of proof and 1 for your addy and 1 for your SSN. Did you maybe get it done and forgot and flew out of the country or something ?
  14. drjimmy1964 @ drjimmy1964: @bigblueallda are you sure you have a Real ID ? I mean , they really want 6 points of proof and 1 for your addy and 1 for your SSN. Did you maybe get it done and forgot and flew out of the country or something ?
  15. S @ soupson: did anyone ask about real id or is sweet ol jimmy just rambling
  16. T @ Turbo259: @drjimmy1964 what did you mean by advertise? not gettin the verbiage, DM works if anything, just didnt understand
  17. B @ bigblueallda: {Visit your local Driver Service Bureau with the necessary documents: original birth certificate, Social Security card, and two proofs of your state's residency. } I definitely provided this when I had to get a new ID when i let mine go expired too long maybe I unknowingly got one but I think it is pretty standard here.
  18. B @ bigblueallda: Well it was a state id renewal. Before that there was a mixup and I had lost my birth certficate and social security number. After a couple of weeks and finally getting several documents in order I was able to get a state ID. It had been expired previously for a little too long and they wanted all kinds of proof. It was a mess. But nah I looked up what to look for an my state's ID to see if it is a Real Id or not and my card as the symbol it is supposed to have. I'll take a closer look though
  19. drjimmy1964 @ drjimmy1964: @bigblueallda are you sure you have a Real ID ? I mean , they really want 6 points of proof and 1 for your addy and 1 for your SSN. Did you maybe get it done and forgot and flew out of the country or something ?
  20. drjimmy1964 @ drjimmy1964: Actually it says "Not For Real ID Purposes". That is my 2022 renewal of my 2018 picture ID. I am not due till 2026 and I am sure they will make me go in since my pic would be 8 years old - they used to make you go in in my state for aging when I was younger, then went paper - then back to picture ( I think 9/11 to blame for that ) but relaxed it.
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