I think yes and no. It wouldn’t stop me from buying it in a large quantity however if that was what I wanted. Most of the vendors that sell them in huge quantities also spread them out in several shipments. This could either be a good thing or more of a chance of one to get confiscated. If it is purely domestic, that would lessen the chance as their not crossing customs and aren’t scrutinized as much. I’d also read the last 5-10 pages of each vendors thread to see how many packages in the past got seized or ultimately made it. This will show you how well they package their items. Some have great track records with very few seizures (even with large orders) while others seem to have many. This would lend to the likelihood for you.
Good luck and be safe!