Fl-Modafinil

CAHEpiphany

CAHEpiphany

Member
Joined
Feb 24, 2020
Messages
281
Hey there,

Wasn't sure whether to post this here or in nootropic forum, but since I was trying to use for ADHD, I decided to put it here.

Before my time on DBG, I'd been looking for an alternative/supplement to my doctor prescribed ADHD med, Conc3rta. Being scheduled meant it being a pain in the butt to deal with getting refilled, and I wasn't always able to do it immediately. The days between my refills, I was a foggy exhausted mess.

Research led me to modafinil and friends, and due to ease of obtaining, I opted for fl-moda. Received 5g from a reputable source that provided purity testing info. Started with an allergy test of 1mg, seemed to have no reaction, so a few days later tried 100mg, a medium dose. My experience? 

Absolutely nothing. Garbage. Thought it was bunk and they gave me fake testing info. Gave some ADHD friends some samples, the flmoda worked as expected for them, moderate assistance with focus and wakefulness. What gives?

Around the same time, I did some genetic testing out of pure curiosity, and stumbled upon some info elsewhere. Apparently there is such thing as a genetic non responder to the Moda family. And guess who is a non responder? 🙄

So it's interesting how genetics play into effectiveness, but it might be a good option for most people who are unable to see doctors or pay for a notably effective Rx in a pinch. Or find a good, reliable place for real Moda.

Didn't see much info on flmoda on the site, so I hope someone else is able to comment on their experiences with it, positive or negative.

Much love,

CAH

 
@CAHEpiphany Wow, thanks for the fascinating info!  I wasnt aware of genetic markers for non-responder to moda either!!  Do you happen to know the genotypes/phenotypes associated with being a non-responder?  Thanks!

 
@DoomKitty sure, had to do some quick re-learning but it seems SNP RS4680 on the COMT gene is responsible, at least partially - A,A (aka met/met) individuals like me seem to have minimal, if zero, effects from regular Moda, and I'd assume their related compounds as well.

A well known genetic testing site can show your results for that SNP. A redd1t thread I came across broke it down for dummies like me:

Met/Met=AA; High dopamine in prefrontal cortex.
Val/Met=AG; Higher dopamine in prefrontal cortex (not as high as AA).
Val/Val= GG; Lower dopamine in prefrontal cortex
Click to expand...
I hope it's okay to link to pubmed here, I couldn't find any other good sources (I'll take it down if needed):

https://pubmed.ncbi.nlm.nih.gov/19037200/

 
@CAHEpiphany So I have moderate-to-severe ADD also (primarily inattentive), and I've been taking methylphenidate (prescribed to me) for about 12 years now, with two several-year stretches in which I was getting my MPH through Concerta.  I.e., I understand where you're coming from 🙂

Years ago, a narcoleptic friend gave me a few moda pills and I found them kinda "meh".  I didn't feel like sleeping, I guess, but basically nothing in terms of focus, etc.  More recently, I got some F-moda, and it seems about the same.  I can stay awake through long mind-numbingly boring meetings, but I sure as hell can't pay attention to whatever tedious thing longwinded guy #17 is talking about...

I apologize in advance if I'm about to sound condescending or overly didactic, but I think that you're misunderstanding the pubmed article. The authors are looking specifically at cognitive/executive deficits induced by sleep deprivation, and whether mod can ameliorate them, and the authors are looking at the prefrontal cortex .  I think that ADD involves dopamine in the ventral striatum and the dorsolateral PFC.  Not sure if the authors focused down to check into separate regions of the PFC, or looked at the VA.

Still, really cool thought 🙂  I confess that I, too, check my livew3ll0 on a regular basis, and any time I try a new med!

 
Hey no offense taken and definitely not taken as condescension, @vs322, I'm still a noob when it comes to genetics and brain chemistry in general! All good points! Learn something new every day about ADHDs mechanisms in the brain.

I guess my main consideration here, given I was trying something different for my ADHD (also inattentive type), and got zero effects leading to my non responder discovery. Worth noting I also have the blessings of depression causing fatigue... My thought was "well concerta works great for wakefulness, why wouldn't this?"

Maybe this would have been a better thread for nootropics, since ADHD seems to be in a completely different ballpark for those thinking about the Moda/Fl family. Sincerely appreciate the input!

 
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  2. B @ bigblueallda: @drjimmy1964 lol I am actually surprised it is a real ID. I needed those documents because my license had been expired for over a year and I had to start all over. Nothing was in the system. It was a huge mess. I had no clue I was signing up for Real ID. They asked me for the exact same documents that I needed for a State ID Card.
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  4. drjimmy1964 @ drjimmy1964: Sweet Ol' Me asked about Real ID, Stoup. Are you responsive to emails ? LMAO
  5. drjimmy1964 @ drjimmy1964: I smell some Stoup. Is Stoup's on ?
  6. drjimmy1964 @ drjimmy1964: @bigblueallda You win. I am lost. Thought you were surprised your license was a Real ID, now you say you provided those items.
  7. drjimmy1964 @ drjimmy1964: @bigblueallda I was under the impression that you'd need all of the points to get a real ID . I'd check it's validity if you're gonna fly domestic any time soon, just to make sure. Not to tell you what to do, sorry -
  8. B @ bigblueallda: @drjimmy1964 In my state to get a Real ID, I need SS card, Birth Certificate and two proofs of residency. Which I am positive I had to provide to get a new ID when it had been expired.
  9. drjimmy1964 @ drjimmy1964: @Turbo259 advertising - putting in writing for example an negative action to show they are guilty prior to taking action.
  10. B @ bigblueallda: I haven't flown in an airplane in 20 years lol. Can't recall the last government building I have been in either. According to the symbol it tells me I should have on my ID to make it a Real ID I do have one in my state
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  12. drjimmy1964 @ drjimmy1964: @Turbo259 advertising - putting in writing for example an negative action to show they are guilty prior to taking action.
  13. drjimmy1964 @ drjimmy1964: @bigblueallda are you sure you have a Real ID ? I mean , they really want 6 points of proof and 1 for your addy and 1 for your SSN. Did you maybe get it done and forgot and flew out of the country or something ?
  14. drjimmy1964 @ drjimmy1964: @bigblueallda are you sure you have a Real ID ? I mean , they really want 6 points of proof and 1 for your addy and 1 for your SSN. Did you maybe get it done and forgot and flew out of the country or something ?
  15. S @ soupson: did anyone ask about real id or is sweet ol jimmy just rambling
  16. T @ Turbo259: @drjimmy1964 what did you mean by advertise? not gettin the verbiage, DM works if anything, just didnt understand
  17. B @ bigblueallda: {Visit your local Driver Service Bureau with the necessary documents: original birth certificate, Social Security card, and two proofs of your state's residency. } I definitely provided this when I had to get a new ID when i let mine go expired too long maybe I unknowingly got one but I think it is pretty standard here.
  18. B @ bigblueallda: Well it was a state id renewal. Before that there was a mixup and I had lost my birth certficate and social security number. After a couple of weeks and finally getting several documents in order I was able to get a state ID. It had been expired previously for a little too long and they wanted all kinds of proof. It was a mess. But nah I looked up what to look for an my state's ID to see if it is a Real Id or not and my card as the symbol it is supposed to have. I'll take a closer look though
  19. drjimmy1964 @ drjimmy1964: @bigblueallda are you sure you have a Real ID ? I mean , they really want 6 points of proof and 1 for your addy and 1 for your SSN. Did you maybe get it done and forgot and flew out of the country or something ?
  20. drjimmy1964 @ drjimmy1964: Actually it says "Not For Real ID Purposes". That is my 2022 renewal of my 2018 picture ID. I am not due till 2026 and I am sure they will make me go in since my pic would be 8 years old - they used to make you go in in my state for aging when I was younger, then went paper - then back to picture ( I think 9/11 to blame for that ) but relaxed it.
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