GDAs and insulin sensitivity

E

EasyMoneySnip3r

Grand Poobah
Grand Poobah
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May 2, 2021
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GDA's work well. They help retain insulin sensitivity and partition nutrients. Pretty simple answer.  Does anyone use GDAs

 
@Ayyy7393 All I know about them is that if you're going to take berberine you have to be careful since it inhibits CYP2D6 and CYP3A4 so you shouldn't take it with most... fun stuff. And also antidepressants, beta-blockers, I would just avoid that one.

 
@Ayyy7393 I don't know if we can post links so I'll copy paste the list of affected drugs. Most of these will be metabolized more slowly, making them prone to accumulation, which is very dangerous in some cases. A minority need to be metabolized to be activated so they will have a lesser effect. For example c0de1ne and tr@m@dol won't be metabolized into m0rph1ne and 0-dsmt as much respectively and because of that will have little effect.

CYP2D6

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CYP3A4

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The other thing to keep in mind is that unlike some drugs like some SSR1s, we11butrin and some HIV medications, there are very little studies on how much berberine inhibits these 2 enzymes, meaning there could be some deadly combinations in those lists but there's no way of knowing except taking berberine and one of them, which is obciously dangerous.

In my opinion, here's the thing. I take pr1midone for the essential tremor l1thium gives me. Pr1midone is well known to inhibit or induce several enzymes, but because it has been in the market for 50 years we pretty much know if a combination is safe. With berberine you're going into unknown territory and I don't think the risks (OD, liver/kidney failure, death, etc) are worth taking for what's essentially a supplement, specially when you have several alternatives. So I would simply avoid it.

 
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  8. st1ckyf1ng4z @ st1ckyf1ng4z: Especially if they’re using mitragynine as the parent alk to make substitutes. I think it will affect plain leaf too at the very least it will not be as available as it’s been.
  9. st1ckyf1ng4z @ st1ckyf1ng4z: @MorfineOrfan @nameofuser11 That’s wild. But basic supply/demand tho, right? In my area all the leaf has been pulled off shelves,
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  11. nameofuser11 @ nameofuser11: To clarify plain leaf kratom is not a part of this ban. Mitragynine might be fine. 7, psuedo,mgm15 and sr1708 are what are on the table to be banned most likely but hopefully just regulated.
  12. MorfineOrfan @ MorfineOrfan: @st1ckyf1ng4z and yes , there are already indole alkoloids with tweaked scaffolding ready to take the place of 7/mgm, all with mitragynine as their parent alkoloid. The game of wack a mole starts the minute 7 is officially banned. Its 2013 K2 all over
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