general risk assessment for different types of drugs

freejohn7125

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Joined
May 23, 2023
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I would love to get some takes on how to calculate risk of dangerous adulterants (i.e. fent) being added to different substances.

from my limited research so far I've gotten the impression that:

- the media and govt ('one pill can kill') generally overstates both the likelihood and the magnitude of potential risk in fentanyl being added to *all kinds* of drugs
- fent is much more likely to be present in *downers* and far less likely to be an issue with stimulants (meth, amphetamines, methylphenidate etc.). this is because the effects of fent are unlikely to be confused with those of stimulants.
- regardless, there is some risk of fentanyl 'cross contaminating' with stimulants if manufacturers aren't careful about cleaning scales / presses etc. or make some other mistake. how real is this risk?
- however, fent is most commonly intentionally added to drugs for cost savings reasons (i.e. fent is easier/cheaper to get than whatever drug it's substituting in for). fent is unlikely to be added to drugs that are already relatively cheap to manufacture or obtain.
- *unless*: fent is used to increase the high of a drug with the hope of increasing demand: is this a thing?
- regardless, if fent is unwittingly consumed, the extent to which a dose may be fatal is largely overstated. drug manufacturers/distributers do not want to kill their customers.
- certain ROAs (intravenous, insufflation, smoking??) pose more risk than consuming orally, as digestion slows the rate at which a substance enters the blood stream.
- in addition to test strips, another harm reduction strategy is to consume a new substance in small increments and evaluate effects before increasing dosage
 
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  13. L @ Layne_Cobain: I often wish I lived during the turn of the century or at least before the Harrison narcotics act or whatever I think it was 1924 the fun ended but anyway yeh being able to get laudanum, ❄️ and amphetamine at the local friendly pharmacy
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  19. R @ Royboy99: @malestrom: yeah thats it, my bad Mariani, yeah i considered that and also its ROA, which was oral so the bioavailability was lower than insufflation, higher degree of purity tho and longer duration … there was a significant marked increase of patents filed by Edison during the time it was released in the US. Presidents were known to use it as well, and the Queen. The pope awarded the wine the Vatican gold medal award
  20. Maelstrom @ Maelstrom: I think it was called vin Mariani. But yeah, it was all the rave back in the turn to the 20th century. Original formula Coca Cola did it for a while too. I think it was pretty weak though. Something like 200 mg per liter of wine. Enough to maybe give you a little push but unless you could pound some serious alcohol, it’d be hard to really feel the effects before the ethyl knocked you down on the ground. It was an interesting time period. Laudanum was a “hysterical” woman’s best friend.
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