40mg methylphenidate 3-4hr, dosed bid-tid equates to 10mg Methamphetamine 4-6hr, dosed qd-bid
40mg methylphenidate Extended Release, 3-4hr, dosed qd-bid equates to 5mg Methamphetamine 4-6hr, dosed qd-bid
40mg methylphenidate Sustained Release, 3-4hr, dosed qd-bid equates to 5mg Methamphetamine 4-6hr, dosed qd-bid
Methylphenidate Ritalin 40mg methylphenidate 3-4hr, dosed bid-tid equates to 10mg Methamphetamine 4-6hr, dosed qd-bid
60mg methylphenidate 3-4hr, dosed bid-tid equates to 15mg Methamphetamine 4-6hr, dosed qd-bid
80mg methylphenidate 3-4hr, dosed bid-tid equates to 20mg Methamphetamine 4-6hr, dosed qd-bid
100mg methylphenidate 3-4hr, dosed bid-tid equates to 25mg Methamphetamine 4-6hr, dosed qd-bid
One note of precautions that I found interesting. Please note the manufacturer indicates that human studies to determine upper limit tolerability doses in humans for desoxyn reached maximum effective dose before any signs of toxicity was found, but obviously they could not ethically exceed what was reported to be effective and safe up to a tolerable limit in these subjects at 60mg daily, at which point clinical effectiveness begins to decrease and unwanted effects begin to increase, including recreational reward-reinforcing effects; and here is the extent of the toxicity dose threshold from the manufacturers’ inserts, unfortunately only up to 60mg dose and a recommended clinically effective maximum dose of 25mg for no specific reason other than fear of dependence.
It is nited that neurotoxicity is known to occur in larger doses, but it is expected to require a significantly higher dose and more frequent schedule of administration before evident neurotoxicity is detected and largely is considered as safe as the equivalent drugs for treatment purposes, dependence liability the exception although that is not terribly clear to me why.