NSAIDs for muscle soreness after training

Zottman

Member
Joined
Aug 27, 2016
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30
Funny to read an article about this from last year, bodybuilding . com must be running out of material and re-writing old articles from the vaults.  From April 6, last year:
 

Feeling sore after your last workout? Before you reach for an NSAID like ibuprofen, here's what you need to know about how OTC pain relievers can affect muscle growth.

...

However, before you reach for that bottle of pain pills after your next brutal workout, get the story on how they might impact your results.

...

...there are also performance side effects for the weightlifter to consider. Drugs such as ibuprofen are classified as COX inhibitors, and since COX (cyclooxygenase) activity is a critical component of muscular hypertrophy, there's a clear link: Ibuprofen can inhibit muscular hypertrophy.  In fact, previous research suggests that treatment with ibuprofen can reduce muscle hypertrophy by almost 50 percent, which means that taking a COX inhibitor may very well be counterproductive for muscle gains.
Veeery  interesting.  Except that back in 2002, the group of researchers Trappe, T. A., White, F., Lambert, C. P., Cesar, D., Hellerstein, M., & Evans, W. J. published a study in the  American Journal of Physiology-Endocrinology and Metabolism titled Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis that came to the same conclusion.

13 years ago.

Now I'm not the kind of ultra-scientific bodybuilder who subscribes to periodicals like The American Journal of Physiology-Endocrinology and Metabolism, I have no illusions about being the next Dan Duchaine, but there are trainers and bodybuilders, even power-lifters who read this kind of stuff religiously, and they tell a friend,  who tells a few more friends, until before too long some ambitious writer at one of the Muscle rags picks up on it, orders a copy of the original research, makes it readable for normal humans, and gets it picked by an editor for a front page blurb, hoping that article will make the rag sell 30% more copies than usual and maybe even sell a few hundred subscriptions - That's how you get to be a staff writer, the first step to becoming an associate editor.

This was big news in 2002-2003 (I haven't touched an NSAID for muscle soreness since I first read about it in one of the rags - If I'm absolutely so sore that I can't function, which is rare, I'll take a Tr@madol (for the pain) and a Valium (as a muscle relaxer), and by the next day I'm fine).

So before you shell out $7.50 for a Muscle rag because it has an interesting cover blurb, instead, read the introduction to the article itself right there in the bookstore, then google the subject matter on your phone, or later, when you get home.  9 times out of 10 you'll find the original study behind the article, and that 10th time, you may have to send the publication $10 - $15 for a full copy of the article, because it is behind a paywall.  Original research is always better than an abridged version of it in a Muscle rag.

 
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  1. L @ Layne_Cobain: UessPess tracking is agonizingly stupid 😬 😥
  2. O @ ochemdim: Agreed, apologies all. But at the same time I’ve seen articles about spray bottles that are very expensive. Paying more for less when it comes down to it. I think we should help each other out , but this may not be the spot to discuss this topic, you’re right about that
  3. L @ Layne_Cobain: @ochemdim good stuff as always bro
  4. tiquanunderwood @ tiquanunderwood: got popped*
  5. tiquanunderwood @ tiquanunderwood: Rocky popped. CnC might've dipped.
  6. T @ tito008840: Anyone know what happened to Rocky or cnc?
  7. Dr-Octagon @ Dr-Octagon: See round like a donut
  8. N @ necromedic: @ochemdim : definitely will. I feel like we should have started a thread about this. Apologies, @Admin if this was improper use of the box. Please purge, if necessary.
  9. O @ ochemdim: @necromedic ah ok interesting! Let me know what the researchers find out. The hypothesis makes sense, only thing I’d be wary of is the irritability of VG, and keep in mind, when VG and HCł are mixed, chlorôhýdrín is produced which is very irritating but that’d have to be pretty strong HÇł I believe and just washing before hand will rid the excess HÇł
  10. N @ necromedic: @ochemdim : anecdotally, especially with the way other people have prepared them with just distilled H2O and maybe EtOH or BA for sterility, I would definitely agree, and I’ve wondered if that it’s due to the speed of drainage with such a low weight solvent. That’s why I’ve experimented with adding VG to increase viscosity to let it hang in the NM a little longer. Possibly more diffusion/osmotic pressure with a dry vs hydrated medium?
  11. O @ ochemdim: @Royboy88, @Layne_Cobain, @necromedic in a couple research papers I’ve read, they always found that the sprays had lower absorption rates compared to traditional. I could be wrong but I’d research it if I were doing a study and needed references
  12. L @ Layne_Cobain: @Royboy99 never got to try one of those saline sprays but a snuff bullet is a great compromise love mine Amazon has good ones for cheap
  13. N @ necromedic: @Royboy99: I’ve just held on to one, rinse it with EtOH and refill with saline and VG. You can find the devices, dirt cheap, on a lot of sites.
  14. ms3031 @ ms3031: Anyone ever tried MDBD?
  15. R @ Royboy99: Since C and R are gone sadly are there any vendors that offer ❄️ (c) misters , those were so convenient
  16. tiquanunderwood @ tiquanunderwood: Yeah, be smart, do your research.
  17. M @ meepmoopmeep: is it the high prices from dropshippers? i tend to avoid the obvious dropshippers for that reason
  18. M @ meepmoopmeep: @PlainPasta sorry, but I’m not understanding the issue at hand
  19. tiquanunderwood @ tiquanunderwood: Depends what you're looking for.
  20. P @ PlainPasta: If this is website of sellers who order off the dark web for a premium. We expect a premium back too
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