Pepirine caps

Also known as black pepper extract, biopepine, and a couple other names. 10mg = about 1/4 teaspoon of black pepper. 

It increases the secretion of digestive enzymes so supps/nutrients/vitamins/etc breakdown faster, thereby increasing bioavailability. 

Works great with turmeric (~2000% increase in bioavailability, if I remember correctly). 

Also works with, kratom, adderall, nootropics, nutrient-rich foods in general, coffee, green and black tea, apple cider vinegar... just about everything. 

People that have problems absorbing nutrients take it to increase the effectiveness of therapeutic drugs. It's also why black pepper with spinach, asparagus, broccoli, and brussel sprouts is so damn good. 

I've found it most effective if taken with a small amount of high carb/high fat warm foods like rice and butter; they will cause your body to send more blood to your stomach, further enhancing the effects. Ginger ale (real ginger ale—like Seagrams, not the cheap generic crap) also enhances its effects.

It's been amazing in my experience. 

 
If you're using it for P-glyco protein inhibition stronger and easier more practical options to use are. Proton Pump Inhibitors. Read how PPIs like (stomach acid reducers) Omeprazole or Pantoprazole for example not sure the strongest one is for P-gp Inhibition. It's especially good for something like Adder0l (0pi0ids too) where lowering stomach acidity also increases absorption too for example. Stomach Acid reducers will decrease absorption of vitamins+other supplements @BrokenLeashesAllOverTheFloor mentioned in fact long-term use of stomach acid reducers can cause vitamin/mineral deficiencies due to not enough stomach acid.


The flavonoid supplement Quercetin is known to be a strong P-gp inhibitor too. It's sold as a herbal supplement used for various reasons. Bromelain+Vitamin C increase it's low oral bioavailability. Combining other flavonoids like those in Grapefruit Juice helps too. More than 1000mg of Quercetin daily long-term will cause kidney damage keep that in mind. It's a strong CYP3A4 and CYP1A2 Inhibitor too. If that's a concern for you unlike Omeprazole (Prilosec) which Inhibits CYP3A4 and CYP2C19 Pantoprazole (Tecta) doesn't.


There are others I think. I can't remember right now I'm so sleepy.

 
Well some people say it can't be inhibited. I have read one person say it can take 1-2 weeks to work at least if not longer for inducing CYP2D6 etc, unlike for CYP Inhibition that only takes 2 hours to fully take effect. I don't know about that though I only read it in a post on a nother forum. I think maybe "fully work" possibly...that being said.


St. John's Wort, (I think I know it induces CYP3A4 strongly) I know Valerian Root the higher causes a dose linear CYP2D6 Inhibition (meaning consuming more causes stronger inhibition. A dose of roughly 360MG Ginkgo Biloba to Induce CYP2D6 Alcohol. When I drank half a tall boy (I wouldn't drink more than 1-2 beers without a tolerance to be safe) an hour before taking the Codeine I slowly drank the other half and the Codeine felt a lot better it wasn't placebo I'm to self aware and if I didn't have GABA tolerance at the time I would think it was the Alcohol if it was more than a small amount too. That's why idk if it takes 1-2 weeks along with other cyp idnucing things I did and CYP3A4 inhibiting etc.

When I was reading and scouring google high lol for CYP liver enyzme inducers to make Codeine produce more morphine this was what I found. If that is what your trying to do then Inhibiting CYP3A4 will help in theory by making less Codeine metabolite allowing for more morphine to be converted although the metabolite is now currently believed to contribute the pain relief more than they thought it's just not as strong as the morphine produced by the liver after the initial dose hence they made a time released Codeine Contin Version up to 200mg without Tylenol like 10 years ago.

BTW studies have indicated Codeine can potentially lead to hearing loss as seen with people over a 7 year period. Some poor people lost their hearing 100% completely after their 1st use of Codeine it's something that's always in the back of my mind when I of it so.

 
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  1. ClintEastwood @ ClintEastwood: Just wondering if anyone well trusted has a supply of research thienos or benz in powders for good average prices? Or could give a shout out from me to him? Or the best lowest per each? I’ve seen some cool and some i just know are worth it. Good price rv presses too but it is much more bang for your buck. I have one good vendor. But am looking for variety’s well. Send me a message or reply if you think any. Thanks - CLINT E. Any Heavy stuff too which all seem about the ssmmmmmm
  2. Realbenzeyes @ Realbenzeyes: I always thought I should’ve been born in a much earlier time but I will say, i do enjoy my Xbox and occasional TV series tho 😂
  3. Realbenzeyes @ Realbenzeyes: I just wish the opioid epidemic never happened. Fk the turn of the century (which would be cool no doubt)! Many of my friends and family would’ve ended up in asylums like so many others. I just wish I could get back all those I’ve lost since the start
  4. L @ Layne_Cobain: 1914 I meant
  5. L @ Layne_Cobain: I often wish I lived during the turn of the century or at least before the Harrison narcotics act or whatever I think it was 1924 the fun ended but anyway yeh being able to get laudanum, ❄️ and amphetamine at the local friendly pharmacy
  6. Maelstrom @ Maelstrom: Chew on the leaves with a bit of slaked lime and enjoy the mild boost you get from the raw base.
  7. Maelstrom @ Maelstrom: I’m sure you know the folks in the mountainous regions along South Americas pacific side buy cócà leaves at the local farmers market just to help acclimate to the higher elevation when they have to head up into the hills.
  8. Maelstrom @ Maelstrom: I would certainly have bought it, swilled it, enjoyed it…. Why not? A little boost in your juice isn’t going to hurt anyone.
  9. R @ Royboy99: Exports were reported to have around 7.2mg per FL OZ, it’s success is what actually led to Coca Cola
  10. Maelstrom @ Maelstrom: Having cramps and husband thinks you’re acting hysterical (ie. PMS) the doc would either perform a certain massage to relieve the strains of motherhood and family life of that time or send you down to the local apothecary for a bottle of laudanum… A tincture of alcohol and 10% òpìųm. Fun days huh?
  11. R @ Royboy99: @malestrom: yeah thats it, my bad Mariani, yeah i considered that and also its ROA, which was oral so the bioavailability was lower than insufflation, higher degree of purity tho and longer duration … there was a significant marked increase of patents filed by Edison during the time it was released in the US. Presidents were known to use it as well, and the Queen. The pope awarded the wine the Vatican gold medal award
  12. Maelstrom @ Maelstrom: I think it was called vin Mariani. But yeah, it was all the rave back in the turn to the 20th century. Original formula Coca Cola did it for a while too. I think it was pretty weak though. Something like 200 mg per liter of wine. Enough to maybe give you a little push but unless you could pound some serious alcohol, it’d be hard to really feel the effects before the ethyl knocked you down on the ground. It was an interesting time period. Laudanum was a “hysterical” woman’s best friend.
  13. R @ Royboy99: Maybe it’s the admixture of my South American dna that works so well with it ? 🤷
  14. R @ Royboy99: It’s all evident in memory recall, my emails, meetings, … people invest everything they have in a nootropic that provides this… desperately searching without success and it’s right there right under their nose (no pun) … stigmatized by society and outlawed.
  15. R @ Royboy99: Now I’m not foolish or delusional to think that it made Edison who he was … it just allowed him to Edison to Edison to a greater degree … and I see it doing that for me and others who use it as a productive tool and not a substance of abuse.. you can look at this data with the level of patents filed by Edison during that time … comparable to Barry bonds or McGuire breaking records while they were subtly enhanced
  16. R @ Royboy99: One could argue that we would not have motion pictures if it wasn’t for ❄️
  17. R @ Royboy99: I also take month long breaks and replace with Ritalin for receptor recovery
  18. R @ Royboy99: And while it may sound insane and completely destructive … small microdoses of ❄️ has really transformed me. I did extensive research on its use by Edison, the pope at the time, and many others who got great benefit from a wine concoction called vin Mariani … this subtle enhancement changed the world and as long its used with a high degree of control, it’s amazing. you may think I’m crazy … but I’m just being as transparent as I can
  19. R @ Royboy99: I’ve grown to realize that my time is finite and Im only getting older… I’m back to relying on small PRN doses of FDA trialed BZDs and it’s made tremendous improvements to my quality of life. I just need to get out there more and meet someone new, it’s the only piece that’s missing since I’ve managed to get it together
  20. R @ Royboy99: @LatsDoodis: thanks brother … I’ve spent months trying to put myself in uncomfortable places to grow stronger. Hours of research, thousands on supplements, therapy etc …
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