relative strengtgh of benzos

[greggy]

BENZODIAZEPINE EQUIVALENCE TABLE
(Benzodiazepine Equivalency Table)

Revised April 2007

This Benzodiazepine Equivalence Table is based on the extensive research and clinical experience of Professor C Heather Ashton, DM, FRCP, Emeritus Professor of Clinical Psychopharmacology at the University of Newcastle upon Tyne, England. Sources: NRHA Drug Newsletter, April 1985 and Benzodiazepines: How they Work & How to Withdraw (The Ashton Manual), 2002. The approximate equivalent doses to 10mg diazepam (Valium) are given.

For a discussion of half-lives and equivalencies see also the Benzo FAQ document.



Benzodiazepines1




Half-life (hrs)2
[active metabolite]




Approximately Equivalent
Oral dosages (mg)3




Market Aim4



Alprazolam
(Xanax, Xanor, Tafil)



6-12




0.5




a



Bromazepam
(Lexotan, Lexomil)



10-20




5-6




a



Chlordiazepoxide
(Librium)



5-30 [36-200]




25




a



Clobazam
(Frisium)5



12-60




20




a,e



Clonazepam
(Klonopin, Rivotril)5



18-50




0.5




a,e



Clorazepate
(Tranxene)



[36-200]




15




a



Diazepam
(Valium)



20-100 [36-200]




10




a



Estazolam
(ProSom, Nuctalon)



10-24




1-2




h



Flunitrazepam
(Rohypnol)



18-26 [36-200]




1




h



Flurazepam
(Dalmane)



[40-250]




15-30




h



Halazepam
(Paxipam)



[30-100]




20




a



Ketazolam
(Anxon)



30-100 [36-200]




15-30




a



Loprazolam
(Dormonoct)



6-12




1-2




h



Lorazepam
(Ativan, Temesta, Tavor)



10-20




1




a



Lormetazepam
(Noctamid)



10-12




1-2




h



Medazepam
(Nobrium)



36-200




10




a



Nitrazepam
(Mogadon)



15-38




10




h



Nordazepam
(Nordaz, Calmday)



36-200




10




a



Oxazepam
(Serax, Serenid,
Serepax, Seresta)



4-15




20




a



Prazepam
(Centrax, Lysanxia)



[36-200]




10-20




a



Quazepam (Doral)



25-100




20




h



Temazepam
(Restoril, Normison,
Euhypnos)



8-22




20




h



Triazolam
(Halcion)



2




0.5




h



Non-benzodiazepines
with similar effects 1, 6



 




 




 



Zaleplon
(Sonata)



2




20




h



Zolpidem
(Ambien, Stilnoct, Stilnox)



2




20




h



Zopiclone
(Zimovane, Imovane)



5-6




15




h



Eszopiclone
(Lunesta)



6
(9 in elderly)




3




h

1. All these drugs are recommended for short-term use only (2-4 weeks maximum). See 1988 Guidelines.
   
   
   
2. Half-life: time taken for blood concentration to fall to half its peak value after a single dose. Half-life of active metabolite shown in square brackets. This time may vary considerably between individuals.
   
   
   
3. These equivalents do not agree with those used by some authors. They are firmly based on clinical experience during switch-over to diazepam at start of withdrawal programs but may vary between individuals.
   
   
   
4. Market Aim: Although all benzodiazepines have similar actions, they are usually marketed as anxiolytics (a), hypnotics (h) or anticonvulsants (e).
   
   
   
5. In the UK clobazam (Frisium) and clonazepam (Rivotril) are licensed for use as anti-epileptics only.
   
   
   
6. These drugs are chemically different from benzodiazepines but have the same effects on the body and act by the same mechanisms.
   

 

[Jellopanda]

BENZODIAZEPINE EQUIVALENCE TABLE
(Benzodiazepine Equivalency Table)

Revised April 2007

This Benzodiazepine Equivalence Table is based on the extensive research and clinical experience of Professor C Heather Ashton, DM, FRCP, Emeritus Professor of Clinical Psychopharmacology at the University of Newcastle upon Tyne, England. Sources: NRHA Drug Newsletter, April 1985 and Benzodiazepines: How they Work & How to Withdraw (The Ashton Manual), 2002. The approximate equivalent doses to 10mg diazepam (Valium) are given.

For a discussion of half-lives and equivalencies see also the Benzo FAQ document.



Benzodiazepines1




Half-life (hrs)2
[active metabolite]




Approximately Equivalent
Oral dosages (mg)3




Market Aim4



Alprazolam
(Xanax, Xanor, Tafil)



6-12




0.5




a



Bromazepam
(Lexotan, Lexomil)



10-20




5-6




a



Chlordiazepoxide
(Librium)



5-30 [36-200]




25




a



Clobazam
(Frisium)5



12-60




20




a,e



Clonazepam
(Klonopin, Rivotril)5



18-50




0.5




a,e



Clorazepate
(Tranxene)



[36-200]




15




a



Diazepam
(Valium)



20-100 [36-200]




10




a



Estazolam
(ProSom, Nuctalon)



10-24




1-2




h



Flunitrazepam
(Rohypnol)



18-26 [36-200]




1




h



Flurazepam
(Dalmane)



[40-250]




15-30




h



Halazepam
(Paxipam)



[30-100]




20




a



Ketazolam
(Anxon)



30-100 [36-200]




15-30




a



Loprazolam
(Dormonoct)



6-12




1-2




h



Lorazepam
(Ativan, Temesta, Tavor)



10-20




1




a



Lormetazepam
(Noctamid)



10-12




1-2




h



Medazepam
(Nobrium)



36-200




10




a



Nitrazepam
(Mogadon)



15-38




10




h



Nordazepam
(Nordaz, Calmday)



36-200




10




a



Oxazepam
(Serax, Serenid,
Serepax, Seresta)



4-15




20




a



Prazepam
(Centrax, Lysanxia)



[36-200]




10-20




a



Quazepam (Doral)



25-100




20




h



Temazepam
(Restoril, Normison,
Euhypnos)



8-22




20




h



Triazolam
(Halcion)



2




0.5




h



Non-benzodiazepines
with similar effects 1, 6



 




 




 



Zaleplon
(Sonata)



2




20




h



Zolpidem
(Ambien, Stilnoct, Stilnox)



2




20




h



Zopiclone
(Zimovane, Imovane)



5-6




15




h



Eszopiclone
(Lunesta)



6
(9 in elderly)




3




h

1. All these drugs are recommended for short-term use only (2-4 weeks maximum). See 1988 Guidelines.
   
2. Half-life: time taken for blood concentration to fall to half its peak value after a single dose. Half-life of active metabolite shown in square brackets. This time may vary considerably between individuals.
   
3. These equivalents do not agree with those used by some authors. They are firmly based on clinical experience during switch-over to diazepam at start of withdrawal programs but may vary between individuals.
   
4. Market Aim: Although all benzodiazepines have similar actions, they are usually marketed as anxiolytics (a), hypnotics (h) or anticonvulsants (e).
   
5. In the UK clobazam (Frisium) and clonazepam (Rivotril) are licensed for use as anti-epileptics only.
   
6. These drugs are chemically different from benzodiazepines but have the same effects on the body and act by the same mechanisms.
   

Very interesting read. Do i read the table correctly if that means Z0lp for example is twice the strength of D1@z?

I've heard that thing about benz0s being recommended for short-term use only. Seems that isn't what doctors prescribe tho. There's ton's of people, and i'm guessing many on this forum, who have been on them for years if not decades.

I notice it doesn't mention M1d@z0l@m, which i'm curious about, and i see is available from some of the e-mail vendors, since i'm developing tolerance for d1@z. I've heard it very strong tho and i'm not sure it's even legal in norway. It seems a bit scary tbh, and maybe that's like going from beer to 180 proof absinthe

 

[Smoka90]

Oooh, I love looking at benzodi@zepine tables like this! I've got most of it mapped out in my head, since I keep my bennzoh use very disciplined, I always have to be careful not to go over 20mg di@z equivalent. But you do have to compare lots of different sources, if things like equivalent doses and half life are important to you. I've seen some pretty big differences, like I've seen differences in alpr@z of 0.5mg, which can make all the difference if you're trying to be careful.

I'm obsessed with the half lives too, but it is so dependent on individual metabolism it's virtually impossible to know...

@Jellopanda Mid@z tempted me since it's supposed to be a potent, short lasting hypnotic. Perfect for me! Well, it was...pants. Poo stained pants, at that. This is taking it orally in tablet form, by the way. I think it has a poor oral bioavailability, which doesn't help. I took a 15mg dose, which I thought was massive. I got a *tiny* bit sleepy, that's all. I think that benzoh is more suited to medical settings where it's IV'ed. That's obviously stuff not to be done at home, I'd never dream of injecting myself with anything.

As far as mid@z equivalency goes, I'd say 7.5mg = 10mg of Di@z. I did read somewhere that 3.5mg = 10mg, but since the bioavailability is less than 50%, 7.5mg may be more accurate.

Then again, I could just be talking nonsense. Just my personal experiences there.

If short acting hypnotics are what you're after, then you can join my mission to find the ideal one. The 'z-drugs' are hypnotic and short acting, but zop!clone gives me that horrible metallic taste. Eugh.

Sorry, I did it again. I rambled... =/

 

[Jellopanda]

Oooh, I love looking at benzodi@zepine tables like this! I've got most of it mapped out in my head, since I keep my bennzoh use very disciplined, I always have to be careful not to go over 20mg di@z equivalent. But you do have to compare lots of different sources, if things like equivalent doses and half life are important to you. I've seen some pretty big differences, like I've seen differences in alpr@z of 0.5mg, which can make all the difference if you're trying to be careful.

I'm obsessed with the half lives too, but it is so dependent on individual metabolism it's virtually impossible to know...

@Jellopanda Mid@z tempted me since it's supposed to be a potent, short lasting hypnotic. Perfect for me! Well, it was...pants. Poo stained pants, at that. This is taking it orally in tablet form, by the way. I think it has a poor oral bioavailability, which doesn't help. I took a 15mg dose, which I thought was massive. I got a *tiny* bit sleepy, that's all. I think that benzoh is more suited to medical settings where it's IV'ed. That's obviously stuff not to be done at home, I'd never dream of injecting myself with anything.

As far as mid@z equivalency goes, I'd say 7.5mg = 10mg of Di@z. I did read somewhere that 3.5mg = 10mg, but since the bioavailability is less than 50%, 7.5mg may be more accurate.

Then again, I could just be talking nonsense. Just my personal experiences there.

If short acting hypnotics are what you're after, then you can join my mission to find the ideal one. The 'z-drugs' are hypnotic and short acting, but zop!clone gives me that horrible metallic taste. Eugh.

Sorry, I did it again. I rambled... =/

Really what i'm after is something that reduces anxiety as much as possible without too many drawbacks. I've just read that Mid@z is very potent, but have no experience with that myself. Short-acting isn't important to me. In fact longer acting is a plus, as when i need to be social for longer periods of time i'd like to be on something that effectively manages my anxiety without constantly re-dosing myself. Alcohol used to be my go to drug for that, but as i've explained elsewhere, that has severely impacted me both physically and mentally. With some experience in that department i agree with the people who say that alcohol is one of the worst drugs there is.

 

[Smoka90]

@Jellopanda Ah, okay, I get you now. Luckily there's going to be quite a lot of options for you.

I don't know where to start. Erm... I'd say brom@zepam is what you want. It's intermediate lasting, half life of around 16 hours, is very low on sedation and has wonderful anxiety relief. It's not quite euphoric (there are some benzohs that give me euphoria), but there is a definite mood lift. I used to use it a lot when I had to meet new people and go to new places. I was always pretty much fully functional on it (I say 'pretty much' because I'm *never* fully functional!). 6mg is equivalent to 10mg di@z. It's also pretty easy to get hold of in my experience.

There's also pyrazolam. It's technically a research chemical, but it's not like it's anywhere near as risky as some RCs. It was even developed by La Roche, so I'd definitely feel safe using it. Quite low dose (1-1.5mg), quite short acting, but I'd say it has the least sedation of any benzoh I've ever tried, by a long, long way. There's just zero wooziness. It's something I may have used for interviews and things in times past. It's extremely functional. I think from your angle the only downside would be the duration.

There's also phenibut. Have you heard of it? It's not a benzoh, it works in a similar way to baclofen. At moderate doses it's very subtle, but I can tell you it can make you very, very confident, motivated and anxiety free. No sedation at all on sensible doses. The bad news is it can take at least 2 hours to kick in, but the good news is that it lasts for at least 12 hours, often longer.

Do be careful with addiction and tolerance, though... I mean, I agree with your thoughts on alcohol. I used to binge drink every single night, was pretty grim. I quit just over two years ago. I've got an op8 dependency as well. But I respect benzohs because, wow, a benzoh addiction scares me a lot, despite all the addictions I've had and still have.

So, yeah... I hope this helps. =)

 

[blissopifree 2]

Hey @Smoka90 your list of addiction is almost identical to mines,benzos also terrify me also and I ALLWAYS say I have enough addictions allready and MOST certainly don't want another!.

Peace 

Bliss....