I have been through a huge list of antidepressants, from SSRIs to beta blockers, honestly I couldn't even remember everything that my doctor has prescribed for me to try. Effexor most recently.... which did absolutely nothing for me. Right now the only thing that truly helps me is yoga, becoming really active with learning how to "jam Skate" ( artistic roller skating/tricks,etc.), losing weight (I'm 5'3" and went from 160 to 105).... and very clean, healthy eating ( that means different things for different people, for me it meant a paleo diet and going kerogenic a couple times per month). Lots of water, no soda/junk food, low carb intake (NO sugar other than the rare special occasion). I'm not going to say my depression is gone, it's not. But most of the time I can function and even have my good days when I feel very little depression. I used to live in a constant state of lethargy, negativity and I just had a huge case of the fuck its. I have a lot of home stress, a severely disabled child with cerebral palsy/epilepsy/developmental delays (he has the developmental age of a one-year-old but he's actually 18), an 8 year old, and art related home business I share with my husband, a marriage that has issues...and to top it off I'm an addict going through a slow taper from some serious meds ( I am convinced that the medication in and of itself is one of the root causes of my depression... Suboxone). I have anxiety/panic attacks, those started when was very young and accelerated when my son's seizures began. My husband thinks I'm simply stuck in the "mindset" of having anxiety and depression issues. " Force yourself to smile!"... sometimes I just want to scream when he says that to me. It's easy to say crap like that from the outside, but he is not in my head or a living my emotional life. When I skate, most of the time, my anxiety and depression melt away and I feel completely free. This isn't always the case, but more often than not. I still wonder if finding the right antidepressant would help me. I have no idea. I still have those days where I just have zero motivation to move, work or do much of anything besides a lay around like a couch potato with my own personal black rain cloud over my head. I am far from an expert on depression! Probably the opposite. I just saw this thread and thought that I would share my own personal experiences. Now I have to go watch that YouTube video that someone posted! I am working very hard to get off of the medication, and I'm very curious to see how I feel when my detox is complete. I've been on one form of opiod maintenance for 20 years now.