Anybody have some good info on 9-hydroycorynantheidine (also known as C9)?

[RemoteBiscoff]

I've purchased some 9-hydroycorynantheidine, sold under the name "C9", in 50mg tablets. I've haven't received them yet but I'm curious if anyone else has any experience with this new 7OH alternative? The seller told me it's approximately 2x stronger than 7OH and I've heard it may not cause tolerance as quickly as 7OH or Pseudoindoxyl although I have not seen any scientific studies backing this nor trusted anecdotal experiences (but that's because this substance is very, very new).

Let me know if you have tried this! I'll update when I get my stuff in. Thanks guys!

 

[Toad665]

I'm not familiar with this alkaloid but hopefully it's promising! I'm a long time user of leaf and mit and have added 7 in the last year or so. Also have taken MGM as well. But all these minor alkaloids could have potential. Please keep us posted. Is the vendor clear net?

 

[noclipuser]

Not seeing any sort of sites even related to this chem, and you can buy it? Lmao

 

[sporidicus]

I think that stuff was causing liver failure!! I could be wrong, I'll look it up and edit this but to get this out quickly: HOLD OFF! EDIT: I think I was thinking of the cat claw or rhodiola stuff, nevermind!

 

[sporidicus]

I've purchased some 9-hydroycorynantheidine, sold under the name "C9", in 50mg tablets. I've haven't received them yet but I'm curious if anyone else has any experience with this new 7OH alternative? The seller told me it's approximately 2x stronger than 7OH and I've heard it may not cause tolerance as quickly as 7OH or Pseudoindoxyl although I have not seen any scientific studies backing this nor trusted anecdotal experiences (but that's because this substance is very, very new).

Let me know if you have tried this! I'll update when I get my stuff in. Thanks guys!

Mind if I ask where you got it? Some good info here:

https://www.reddit.com/r/KratomAlternatives/comments/p9kkhz/speciociliatine_and_9hydroxycorynantheidine

 

[sporidicus]

The Cayman writeup. Interesting, it is 9-O-DSM-Mit.

9-O-desmethyl Mitragynine (CAS 425623-55-8)

An Analytical Reference Standard

www.caymanchem.com

 

[Rawling]

I think it's 3-Furanyl mitragynine.

https:// pubs.acs.org/doi/10.1021/acs.jmedchem.1c01273

Its a long read but it goes into depth on what it is.

C9 is for is for the substitutions in the 9 position on the indole ring. Compound 6 is just the classification used in the paper, and has nothing to do with the c9 name.

Some quotes-

'Three synthesized lead C9 analogs replacing the 9-OCH3 group with phenyl (4), methyl (5), or 3′-furanyl [6 (SC13)]'

'Compound 6 (SC13) shows MOR-dependent antinociception and lacks abuse potential, constipation, respiratory depression, and hyperlocomotion at equianalgesic morphine doses.'

'In these assays, using either hMOR or mMOR, 4, 5, and 6 (SC13) was found to have similar efficacy to buprenorphine. While the putatively biased MOR ligands SR17018, TRV130, and PZM21 were not evaluated in our study, we infer that 4, 5, and 6 (SC13) may have efficacy similar to SR17018 (20%) but lower than either TRV130 (42%) or PZM21 (38%).'

'In mice, 6 (SC13) was equipotent to morphine in antinociception assays.'

 

[Rawling]

Not to double post, but in case anyone reading the thread isn't aware, it's being referred to as both SC-13 and C9. The company that is doing samples is referring to it as both, although seems to be sticking to C9 on their packaging. Reddit has some reviews from the past couple of weeks. Seems like a sister company of phantomvein kratom, a company I hadn't even heard of, so I'm not gonna list the other company in case this ends bad, but if you really want to know, digging on Reddit will can find it.