Anyone with migraine experience....

@alixjones2018 It's not ideal because they have a tendency to generate tolerance as well as rebound headaches, most doctors told my mom to try to limit her usage to less than 3 times a week, the one exception to this I've heard of is frovatriptan which has such a long half life that it can be used for prophylaxis. The other thing is that for most people triptans are the most effective abortive medication available. If you overuse then you get migraines that you can't treat. It's like using opioids when you could have used NSAIDs, once tolerace happens the pain can get worse than before.

PS: If someone takes frovatriptan or another one everyday and it works for them, awesome, I just think it's not worth the risk when there are many other options.

 
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  2. N @ necromedic: @ochemdim : definitely will. I feel like we should have started a thread about this. Apologies, @Admin if this was improper use of the box. Please purge, if necessary.
  3. O @ ochemdim: @necromedic ah ok interesting! Let me know what the researchers find out. The hypothesis makes sense, only thing I’d be wary of is the irritability of VG, and keep in mind, when VG and HCł are mixed, chlorôhýdrín is produced which is very irritating but that’d have to be pretty strong HÇł I believe and just washing before hand will rid the excess HÇł
  4. N @ necromedic: @ochemdim : anecdotally, especially with the way other people have prepared them with just distilled H2O and maybe EtOH or BA for sterility, I would definitely agree, and I’ve wondered if that it’s due to the speed of drainage with such a low weight solvent. That’s why I’ve experimented with adding VG to increase viscosity to let it hang in the NM a little longer. Possibly more diffusion/osmotic pressure with a dry vs hydrated medium?
  5. O @ ochemdim: @Royboy88, @Layne_Cobain, @necromedic in a couple research papers I’ve read, they always found that the sprays had lower absorption rates compared to traditional. I could be wrong but I’d research it if I were doing a study and needed references
  6. L @ Layne_Cobain: @Royboy99 never got to try one of those saline sprays but a snuff bullet is a great compromise love mine Amazon has good ones for cheap
  7. N @ necromedic: @Royboy99: I’ve just held on to one, rinse it with EtOH and refill with saline and VG. You can find the devices, dirt cheap, on a lot of sites.
  8. ms3031 @ ms3031: Anyone ever tried MDBD?
  9. R @ Royboy99: Since C and R are gone sadly are there any vendors that offer ❄️ (c) misters , those were so convenient
  10. tiquanunderwood @ tiquanunderwood: Yeah, be smart, do your research.
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