AP-238.hcl in stock.

bigjackchen

bigjackchen

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AP-238 is an opioid analgesic drug that was widely used in China to treat pain in cancer patients as of 1986. It is one of the most potent compounds among a series of analgesic acyl piperazine compounds first synthesized and reported in Japan in the 1970s. AP-238 has analgesic potency 4-5times of morphine but with a relatively higher therapeutic index. The drug was initially claimed to be a non-narcotic analgesic. However, subsequent studies have shown bucinnazine and similar acyl piperazines to be potent and selective agonists of μ-opioid receptor (MOR) with relatively low affinity for the δ-opioid receptor and the κ-opioid receptor. In accordance with these studies, results from the intravenous self-administration experiments in rats showed that ap-238 has a marked reinforcing effect with tolerance and dependence quickly developing In addition, the morphine antagonist naloxone reverses the effect of ap-238 and precipitates withdrawal symptoms in ap-238 treated rats further indicating a mechanism of analgesia mediated via selective agonist activity at μ-opioid receptors.

This product is intended for research and forensic applications.

 
Great information, kinda hard to find this one. I did ordered some, we'll see how it goes.

 
The information are correct, except AP-238 is a made-up name. But the structure has been revealed. It's an AP237 analogue/derivate. Still, it's true the currently potency SHOULD be 4-5x, If it will be euphoric or purely sedative, we'll know in a few days.

 
I'll probably grab some at one point or another but duration just looks so disappointing. 237 was/is such a tease to me and this doesn't seem much better, hah

 
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  1. st1ckyf1ng4z @ st1ckyf1ng4z: Especially if they’re using mitragynine as the parent alk to make substitutes. I think it will affect plain leaf too at the very least it will not be as available as it’s been.
  2. st1ckyf1ng4z @ st1ckyf1ng4z: @MorfineOrfan @nameofuser11 That’s wild. But basic supply/demand tho, right? In my area all the leaf has been pulled off shelves,
  3. J @ j00ciiez: It sucks they're banning sr17. It seems to be a holy grail for many ppl.
  4. nameofuser11 @ nameofuser11: To clarify plain leaf kratom is not a part of this ban. Mitragynine might be fine. 7, psuedo,mgm15 and sr1708 are what are on the table to be banned most likely but hopefully just regulated.
  5. MorfineOrfan @ MorfineOrfan: @st1ckyf1ng4z and yes , there are already indole alkoloids with tweaked scaffolding ready to take the place of 7/mgm, all with mitragynine as their parent alkoloid. The game of wack a mole starts the minute 7 is officially banned. Its 2013 K2 all over
  6. st1ckyf1ng4z @ st1ckyf1ng4z: @MorfineOrfan Also, it’s just a matter of time before another alternative pops up on the market anyway….
  7. st1ckyf1ng4z @ st1ckyf1ng4z: @MorfineOrfan I couldn’t agree more, bro. It’s fucked up. I recognize prices will rise, but it will always be available…. Stock up now while you can at least if you’re preferred read is opiates. As an ex-fentanyl addict I won’t ever touch any of that shit again. I remember when I started to see 7oh pop up, I knew it was going to end like this but I can understand getting rid of 7oh/mgm-15/16. With that being said, they should leave plain leaf alone!
  8. MorfineOrfan @ MorfineOrfan: @st1ckyf1ng4z oh trust, i know that, im helping a pretty big vendor transition, to here and dnm , but prices are going to rise bc of risk. But availability is only part of this whole kratom alks situation. We have a serious problem with society. Last year alcohol killed 178,000 people, last year all other drugs combined killed 69,973 Out of those 38,084 were from opiate/opioids and out of those 0 were killed by 7oh. With these numbers we can see the problem with banning 7oh
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