AP-238.hcl in stock.

bigjackchen

bigjackchen

Member
VENDOR ACCOUNT
Joined
Jun 30, 2019
Messages
524
AP-238 is an opioid analgesic drug that was widely used in China to treat pain in cancer patients as of 1986. It is one of the most potent compounds among a series of analgesic acyl piperazine compounds first synthesized and reported in Japan in the 1970s. AP-238 has analgesic potency 4-5times of morphine but with a relatively higher therapeutic index. The drug was initially claimed to be a non-narcotic analgesic. However, subsequent studies have shown bucinnazine and similar acyl piperazines to be potent and selective agonists of μ-opioid receptor (MOR) with relatively low affinity for the δ-opioid receptor and the κ-opioid receptor. In accordance with these studies, results from the intravenous self-administration experiments in rats showed that ap-238 has a marked reinforcing effect with tolerance and dependence quickly developing In addition, the morphine antagonist naloxone reverses the effect of ap-238 and precipitates withdrawal symptoms in ap-238 treated rats further indicating a mechanism of analgesia mediated via selective agonist activity at μ-opioid receptors.

This product is intended for research and forensic applications.

 
Great information, kinda hard to find this one. I did ordered some, we'll see how it goes.

 
The information are correct, except AP-238 is a made-up name. But the structure has been revealed. It's an AP237 analogue/derivate. Still, it's true the currently potency SHOULD be 4-5x, If it will be euphoric or purely sedative, we'll know in a few days.

 
I'll probably grab some at one point or another but duration just looks so disappointing. 237 was/is such a tease to me and this doesn't seem much better, hah

 
You must log in or register to reply here.
Drugbuyersguide Shoutbox
  1. MorfineOrfan @ MorfineOrfan: The major plain leaf companies and the AKA are the ones lobbying against 7 and the other semi-sythetic derivatives, mgm this that and the other. We all know the chemist are just gonna mess with the scaffolding of the compounds and come out with new and even better semi-sythetic alkoloids of kratom. They are already playing with cats-claw
  2. MorfineOrfan @ MorfineOrfan: @moai just asked chatgpeetea and it looks like plain leaf kratom is safe, they arent banning it. Just 7-Hydroxymitragynine, MGM15 ,16 , and pseudoindoxyl
  3. MorfineOrfan @ MorfineOrfan: Wait... @moai they are federally banning plain leaf kratom too???
  4. moai @ moai: @MorphineOrfan how fucking stupid is this shit. We better see some new shit come out, I’m most upset about banning regular kratom because really? Millions of people have got off hard opioids with it. They must want everyone on methadone instead.
  5. F @ frankie dicks: Gil
  6. F @ frankie dicks: Ghb
  7. Gulp2788 @ Gulp2788: If bans were done to logic so much of what is illegal now would end up prescription only and I think the powers that be react faster than they think... if they think at all
  8. MorfineOrfan @ MorfineOrfan: They aren't specifically targeting SR and 7oh
  9. MorfineOrfan @ MorfineOrfan: @RiftChems well sr-17018 is an orphine analogue after all, and they are banning all orphines so that makes sense. Orphines are spiking the OD death rates majorly these past few months.
  10. AlHoffman69 @ AlHoffman69: CANDYMAN ramnemnber thta is will be conme relevenaent soon :alien: :cool: :cool: :cool: 🤑
  11. RiftChems @ RiftChems: crazy they are banning SR17018 at the same time. they know what theyre doing.
  12. nameofuser11 @ nameofuser11: The ban of 7oh is gonna have a lot of people needing help soon. Assuming they do ban instead of regulate like they should
  13. AlHoffman69 @ AlHoffman69: shout out to all our vets and citizens this is our day of pride love all of ya 🌭
  14. st1ckyf1ng4z @ st1ckyf1ng4z: Happy Independence Day my fellow DBG Americans!
  15. novedexrex @ novedexrex: Somebody has a potential gold mine there.
  16. novedexrex @ novedexrex: 7-oh
  17. moai @ moai: @Rod Swanson what about it
  18. R @ Rod Swanson: Pyrazolam
  19. moai @ moai: 7-OH, Kratom itself, are now banned in my state. I’m dependent on 7oh and don’t have much left. I’m going to need SR-17018 or something ASAP, I’ve been needing to get off anyway, but I’m begging anyone to help me in one direction or another.
  20. AlHoffman69 @ AlHoffman69: His dbg name, last name is Prophet full name on his email is "Dean Prophet" SCAMMER he ussed my dbg pofile to ty toi scam hr sood for her shde already knoew me and knew it was not jy witintg or tyoe
Back
Top