AP-238.hcl in stock.

bigjackchen

bigjackchen

Member
VENDOR ACCOUNT
Joined
Jun 30, 2019
Messages
524
AP-238 is an opioid analgesic drug that was widely used in China to treat pain in cancer patients as of 1986. It is one of the most potent compounds among a series of analgesic acyl piperazine compounds first synthesized and reported in Japan in the 1970s. AP-238 has analgesic potency 4-5times of morphine but with a relatively higher therapeutic index. The drug was initially claimed to be a non-narcotic analgesic. However, subsequent studies have shown bucinnazine and similar acyl piperazines to be potent and selective agonists of μ-opioid receptor (MOR) with relatively low affinity for the δ-opioid receptor and the κ-opioid receptor. In accordance with these studies, results from the intravenous self-administration experiments in rats showed that ap-238 has a marked reinforcing effect with tolerance and dependence quickly developing In addition, the morphine antagonist naloxone reverses the effect of ap-238 and precipitates withdrawal symptoms in ap-238 treated rats further indicating a mechanism of analgesia mediated via selective agonist activity at μ-opioid receptors.

This product is intended for research and forensic applications.

 
Great information, kinda hard to find this one. I did ordered some, we'll see how it goes.

 
The information are correct, except AP-238 is a made-up name. But the structure has been revealed. It's an AP237 analogue/derivate. Still, it's true the currently potency SHOULD be 4-5x, If it will be euphoric or purely sedative, we'll know in a few days.

 
I'll probably grab some at one point or another but duration just looks so disappointing. 237 was/is such a tease to me and this doesn't seem much better, hah

 
You must log in or register to reply here.
Drugbuyersguide Shoutbox
  1. C @ corvidae: .
  2. Admin @ Admin: Reminder to vendor's, no shop talk in shoutbox
  3. MrFuszy @ MrFuszy: Because im not fixing to spend money on that brom unless i know for sure that shits gonna land and be good, because I am a nightmare to deal with when i get scammed or fkd over! Like all the way left
  4. MrFuszy @ MrFuszy: Wait how so? Pm me?
  5. st1ckyf1ng4z @ st1ckyf1ng4z: FX sketches me out… you can always buy the cath next week and you’ll be glad to have br0m for landing gear
  6. MrFuszy @ MrFuszy: Gone!
  7. MrFuszy @ MrFuszy: Probably lose like 60 pounds and shit, some dope whore slumped over on the couch....
  8. MrFuszy @ MrFuszy: But damnit I want to stock up on that apvp shit, if its even 1 3rd as good as people make it sound, being better then aphip, man i want 200grams of that shit. You wont see or hear from me for months
  9. MrFuszy @ MrFuszy: Personally i love the fact they got aphip too, but the shipping 30$ no track. Almost feels like a gamble. I mean i dont see why it wouldnt land, but then I'd still need to get 500ml of pg and bottle it. Yeah I think your right it would last alot longer
  10. MrFuszy @ MrFuszy: It would be r4om that fx person
  11. st1ckyf1ng4z @ st1ckyf1ng4z: @MrFuszy br0m will last much longer
  12. MrFuszy @ MrFuszy: Another hassle is dmt, making its stupid easy, jist takes a little time, but then there are the prices for it ready made to go and it's just like -_- well fuck which do i feel like compromising, my time or my money... But then again its dmt and it's fun as fuck
  13. MrFuszy @ MrFuszy: To buy 5g of apvp or 1g bromazolam powder 😭 choices
  14. st1ckyf1ng4z @ st1ckyf1ng4z: @eswen444 might be a little more difficult and involve a little more planning, as well as price increases on certain items, but all of those will still be available, trust.
  15. st1ckyf1ng4z @ st1ckyf1ng4z: @MorfineOrfan i’m sure they made good money off of it and took the shit off the shelves, but I bet you it’s still available if you ask for it upon request especially if they know your regular buyer. I, like you, just bought kilos online to save money back in the day. I would only buy your shit from the smoke shops if I was that desperate.
  16. st1ckyf1ng4z @ st1ckyf1ng4z: @MorfineOrfan like I said before I’m a recovering opiate addict so I choose not to touch the shit at all but I’ve been to smoke shops because I buy disposable vape products and other accessories, but every smoke shop I’ve been to over the last few years have had kratom “front and center” and easy to see. About 2/3 years ago 7oh products began appearing and it got completely out of control. I remember telling one of the owners of my regular shop that 7oh it’s not gonna end well
  17. E @ eswen444: *or post here. Holy spelling problems....but also for everyones info what im told is as of 8/1/2026 7oh, MIT, MGM, and other concentrates will be scheduled 1. Its an emergency schedule which lasts TWO YEARS and they can request an additional if needed. I feel horrible for all the homie/homettes who have to deal with this.
  18. E @ eswen444: @MorfineOrfan do you have a link to the chems the DEA blans to emergency schedule? If so please pm it to me or lost here. From what im told from my corporate over seers everything BUT raw leaf, and capsuled leaf will be removed from shelves 7/31/26
  19. MorfineOrfan @ MorfineOrfan: We made it to another Friday ladies and gents. Hope everyone has a wonderful weekend, be safe out there.
  20. MorfineOrfan @ MorfineOrfan: @st1ckyf1ng4z i have no clue what the supply and demand is like for brick and mortar shops, i havnt been in a smokeshope in 15-20years and back then none of them had or even knew what kratom was. Ive always bought kratom from vendors online, back in tge day we would use babel fish translator to haggle with vendors on kilo prices lol. But you dont need to worry mit will always be available if leaf is.
Back
Top