AP-238.hcl in stock.

bigjackchen

bigjackchen

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AP-238 is an opioid analgesic drug that was widely used in China to treat pain in cancer patients as of 1986. It is one of the most potent compounds among a series of analgesic acyl piperazine compounds first synthesized and reported in Japan in the 1970s. AP-238 has analgesic potency 4-5times of morphine but with a relatively higher therapeutic index. The drug was initially claimed to be a non-narcotic analgesic. However, subsequent studies have shown bucinnazine and similar acyl piperazines to be potent and selective agonists of μ-opioid receptor (MOR) with relatively low affinity for the δ-opioid receptor and the κ-opioid receptor. In accordance with these studies, results from the intravenous self-administration experiments in rats showed that ap-238 has a marked reinforcing effect with tolerance and dependence quickly developing In addition, the morphine antagonist naloxone reverses the effect of ap-238 and precipitates withdrawal symptoms in ap-238 treated rats further indicating a mechanism of analgesia mediated via selective agonist activity at μ-opioid receptors.

This product is intended for research and forensic applications.

 
Great information, kinda hard to find this one. I did ordered some, we'll see how it goes.

 
The information are correct, except AP-238 is a made-up name. But the structure has been revealed. It's an AP237 analogue/derivate. Still, it's true the currently potency SHOULD be 4-5x, If it will be euphoric or purely sedative, we'll know in a few days.

 
I'll probably grab some at one point or another but duration just looks so disappointing. 237 was/is such a tease to me and this doesn't seem much better, hah

 
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  1. st1ckyf1ng4z @ st1ckyf1ng4z: @eswen444 might be a little more difficult and involve a little more planning, as well as price increases on certain items, but all of those will still be available, trust.
  2. st1ckyf1ng4z @ st1ckyf1ng4z: @MorfineOrfan i’m sure they made good money off of it and took the shit off the shelves, but I bet you it’s still available if you ask for it upon request especially if they know your regular buyer. I, like you, just bought kilos online to save money back in the day. I would only buy your shit from the smoke shops if I was that desperate.
  3. st1ckyf1ng4z @ st1ckyf1ng4z: @MorfineOrfan like I said before I’m a recovering opiate addict so I choose not to touch the shit at all but I’ve been to smoke shops because I buy disposable vape products and other accessories, but every smoke shop I’ve been to over the last few years have had kratom “front and center” and easy to see. About 2/3 years ago 7oh products began appearing and it got completely out of control. I remember telling one of the owners of my regular shop that 7oh it’s not gonna end well
  4. E @ eswen444: *or post here. Holy spelling problems....but also for everyones info what im told is as of 8/1/2026 7oh, MIT, MGM, and other concentrates will be scheduled 1. Its an emergency schedule which lasts TWO YEARS and they can request an additional if needed. I feel horrible for all the homie/homettes who have to deal with this.
  5. E @ eswen444: @MorfineOrfan do you have a link to the chems the DEA blans to emergency schedule? If so please pm it to me or lost here. From what im told from my corporate over seers everything BUT raw leaf, and capsuled leaf will be removed from shelves 7/31/26
  6. MorfineOrfan @ MorfineOrfan: We made it to another Friday ladies and gents. Hope everyone has a wonderful weekend, be safe out there.
  7. MorfineOrfan @ MorfineOrfan: @st1ckyf1ng4z i have no clue what the supply and demand is like for brick and mortar shops, i havnt been in a smokeshope in 15-20years and back then none of them had or even knew what kratom was. Ive always bought kratom from vendors online, back in tge day we would use babel fish translator to haggle with vendors on kilo prices lol. But you dont need to worry mit will always be available if leaf is.
  8. MorfineOrfan @ MorfineOrfan: @nameofuser11 its not just 7/mgm/psuedo and sr, the dea has a huge list of compounds its banning with this ban. Odsmt is one, all the orphines and a ton more.
  9. MrFuszy @ MrFuszy: Lole onion sites?
  10. MrFuszy @ MrFuszy: @eiffraffca what ya mean
  11. R @ Riffraffca: Has anyone used and markets on the Dark Web?
  12. st1ckyf1ng4z @ st1ckyf1ng4z: @nameofuser11 Lol, happens to the best of us my friend. I think plain leaf will remain pretty easy to access, and prices shouldn’t fluctuate too much. Read up on how to use btc if you don’t know already. It’s not rocket science :)
  13. nameofuser11 @ nameofuser11: I donated and I forgot how to get the password. I am a moron. Don't worry I have no plans on becoming a vendor with my stupidity
  14. nameofuser11 @ nameofuser11: @st1ckyf1ng4z you're right of course. But being able to purchase with a debit card on a clearnet site with quality labs and low prices will be gone.
  15. st1ckyf1ng4z @ st1ckyf1ng4z: Especially if they’re using mitragynine as the parent alk to make substitutes. I think it will affect plain leaf too at the very least it will not be as available as it’s been.
  16. st1ckyf1ng4z @ st1ckyf1ng4z: @MorfineOrfan @nameofuser11 That’s wild. But basic supply/demand tho, right? In my area all the leaf has been pulled off shelves,
  17. J @ j00ciiez: It sucks they're banning sr17. It seems to be a holy grail for many ppl.
  18. nameofuser11 @ nameofuser11: To clarify plain leaf kratom is not a part of this ban. Mitragynine might be fine. 7, psuedo,mgm15 and sr1708 are what are on the table to be banned most likely but hopefully just regulated.
  19. MorfineOrfan @ MorfineOrfan: @st1ckyf1ng4z and yes , there are already indole alkoloids with tweaked scaffolding ready to take the place of 7/mgm, all with mitragynine as their parent alkoloid. The game of wack a mole starts the minute 7 is officially banned. Its 2013 K2 all over
  20. st1ckyf1ng4z @ st1ckyf1ng4z: @MorfineOrfan Also, it’s just a matter of time before another alternative pops up on the market anyway….
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