AP-238.hcl in stock.

bigjackchen

bigjackchen

Member
VENDOR ACCOUNT
Joined
Jun 30, 2019
Messages
524
AP-238 is an opioid analgesic drug that was widely used in China to treat pain in cancer patients as of 1986. It is one of the most potent compounds among a series of analgesic acyl piperazine compounds first synthesized and reported in Japan in the 1970s. AP-238 has analgesic potency 4-5times of morphine but with a relatively higher therapeutic index. The drug was initially claimed to be a non-narcotic analgesic. However, subsequent studies have shown bucinnazine and similar acyl piperazines to be potent and selective agonists of μ-opioid receptor (MOR) with relatively low affinity for the δ-opioid receptor and the κ-opioid receptor. In accordance with these studies, results from the intravenous self-administration experiments in rats showed that ap-238 has a marked reinforcing effect with tolerance and dependence quickly developing In addition, the morphine antagonist naloxone reverses the effect of ap-238 and precipitates withdrawal symptoms in ap-238 treated rats further indicating a mechanism of analgesia mediated via selective agonist activity at μ-opioid receptors.

This product is intended for research and forensic applications.

 
Great information, kinda hard to find this one. I did ordered some, we'll see how it goes.

 
The information are correct, except AP-238 is a made-up name. But the structure has been revealed. It's an AP237 analogue/derivate. Still, it's true the currently potency SHOULD be 4-5x, If it will be euphoric or purely sedative, we'll know in a few days.

 
I'll probably grab some at one point or another but duration just looks so disappointing. 237 was/is such a tease to me and this doesn't seem much better, hah

 
You must log in or register to reply here.
Drugbuyersguide Shoutbox
  1. proton369 @ proton369: 💎💎💎💎💎💎💎💎
  2. G @ Greginj: O dsmt
  3. R @ Royboy99: I invite anyone interested to read my latest review on CG… (wrong vendor identified earlier today it was CG not PD), mods contacted to delete erroneous post, bad case of the oh fuck tonight … but corrected to give credit to whom it was due, nothing against PD… just a mistake on my part … and wanted to give credit to whom it was due
  4. L @ Layne_Cobain: Ohhhh hahah @Royboy99 mine too 🤣
  5. R @ Royboy99: @Layne_Cobain, Freud’s favorite.
  6. L @ Layne_Cobain: Sorry you got burnt @ClintEastwood 😞
  7. L @ Layne_Cobain: What is the nootropic @Royboy99
  8. R @ Royboy99: Roughly 1g in 10-15ml of Saline
  9. R @ Royboy99: Honestly the greatest medication I’ve trialed
  10. R @ Royboy99: And it’s not like I’m geeked out crazy looking or acting , just happy, confident , loving life, productive af, greatest nootropic I’ve experienced
  11. R @ Royboy99: Man I really love these misters I make , it takes my day that’s at a 2 and cranks it up to at least a 9… with sustained reups as needed … if only this was fda approved med lol, make my life so much easier
  12. C @ ClintEastwood: Well I got burned on my first buy. It stral sucks the guy has sole things in stock. But definitely what I ordered and I thought he was honest because I asked for something very close to it and i said what about that one. Yeah I got it. And the comms were wired and he was really wanting me to make his forum board look better. Now I know the first thing to look at even before the menu. But I have some business with usps tomorrow and will ask for everything mailed to me especially packages
  13. Dr-Octagon @ Dr-Octagon: Policies have changed and i would behoove everyone to due their due diligence and go have a look. The guidelines from 5-10 years ago dont apply. And rules, regulations and laws may not either, i mean do you see anyone giving 2 sh1tz about the C0n$tituti@n recently?
  14. Dr-Octagon @ Dr-Octagon: @rasetreydir, yeah those are good af too
  15. Dr-Octagon @ Dr-Octagon: @Ross7223, they should boycott pre-paid p0stage
  16. Dr-Octagon @ Dr-Octagon: @Gulp2788, no they do not as of sept 25, u cant assume everything is the same, or anything for that matter. Its a brave new A-1 world folks.
  17. Gulp2788 @ Gulp2788: My milage has differed to yours though, I've found them incredibly reliable with their tracking and 3 day delivery is pretty accurate.
  18. Gulp2788 @ Gulp2788: I agree but U5PS has to go through a legal process to search packages. Private companies can open your mail at their discretion.
  19. Ross7223 @ Ross7223: @Gulp2788 because they always lose pckgs, track1ng is never right, never is 3 day deliv3ry like they say
  20. Gulp2788 @ Gulp2788: @Ross7223 From my understanding that's actually counter-productive, but maybe you know something I don't. Why do you say that?
Back
Top