AP-238.hcl in stock.

bigjackchen

bigjackchen

Member
VENDOR ACCOUNT
Joined
Jun 30, 2019
Messages
511
AP-238 is an opioid analgesic drug that was widely used in China to treat pain in cancer patients as of 1986. It is one of the most potent compounds among a series of analgesic acyl piperazine compounds first synthesized and reported in Japan in the 1970s. AP-238 has analgesic potency 4-5times of morphine but with a relatively higher therapeutic index. The drug was initially claimed to be a non-narcotic analgesic. However, subsequent studies have shown bucinnazine and similar acyl piperazines to be potent and selective agonists of μ-opioid receptor (MOR) with relatively low affinity for the δ-opioid receptor and the κ-opioid receptor. In accordance with these studies, results from the intravenous self-administration experiments in rats showed that ap-238 has a marked reinforcing effect with tolerance and dependence quickly developing In addition, the morphine antagonist naloxone reverses the effect of ap-238 and precipitates withdrawal symptoms in ap-238 treated rats further indicating a mechanism of analgesia mediated via selective agonist activity at μ-opioid receptors.

This product is intended for research and forensic applications.

 
Great information, kinda hard to find this one. I did ordered some, we'll see how it goes.

 
The information are correct, except AP-238 is a made-up name. But the structure has been revealed. It's an AP237 analogue/derivate. Still, it's true the currently potency SHOULD be 4-5x, If it will be euphoric or purely sedative, we'll know in a few days.

 
I'll probably grab some at one point or another but duration just looks so disappointing. 237 was/is such a tease to me and this doesn't seem much better, hah

 
You must log in or register to reply here.
Drugbuyersguide Shoutbox
  1. eswen444 @ eswen444: @rockychoc hes not slick in the slightest
  2. xenxra @ xenxra: 👍
  3. rockychoc @ rockychoc: scammer, avoid that email guys
  4. rockychoc @ rockychoc: Heads up to all, <RCxPert@proton.me>
  5. P @ psychedpsych: New PC parts and other devices are a breath of fresh air.
  6. P @ psychedpsych: Lol Mesh... AiMesh, good info. @xenxra
  7. N @ NYStateofMind: my face has freckles
  8. xenxra @ xenxra: Mesh on my face 'cause I'm faceless
  9. P @ psychedpsych: Have good day people, and I hate texting messages lol
  10. B @ bigblueallda: @drjimmy1964 lol I am actually surprised it is a real ID. I needed those documents because my license had been expired for over a year and I had to start all over. Nothing was in the system. It was a huge mess. I had no clue I was signing up for Real ID. They asked me for the exact same documents that I needed for a State ID Card.
  11. S @ soupson: bless your heart buddy. no sense of grammar or proper insults/jokes. you need this place in ways i can’t comprehend
  12. drjimmy1964 @ drjimmy1964: Sweet Ol' Me asked about Real ID, Stoup. Are you responsive to emails ? LMAO
  13. drjimmy1964 @ drjimmy1964: I smell some Stoup. Is Stoup's on ?
  14. drjimmy1964 @ drjimmy1964: @bigblueallda You win. I am lost. Thought you were surprised your license was a Real ID, now you say you provided those items.
  15. drjimmy1964 @ drjimmy1964: @bigblueallda I was under the impression that you'd need all of the points to get a real ID . I'd check it's validity if you're gonna fly domestic any time soon, just to make sure. Not to tell you what to do, sorry -
  16. B @ bigblueallda: @drjimmy1964 In my state to get a Real ID, I need SS card, Birth Certificate and two proofs of residency. Which I am positive I had to provide to get a new ID when it had been expired.
  17. drjimmy1964 @ drjimmy1964: @Turbo259 advertising - putting in writing for example an negative action to show they are guilty prior to taking action.
  18. B @ bigblueallda: I haven't flown in an airplane in 20 years lol. Can't recall the last government building I have been in either. According to the symbol it tells me I should have on my ID to make it a Real ID I do have one in my state
  19. Gracie5 @ Gracie5: Hey @CuCeltic99!
  20. drjimmy1964 @ drjimmy1964: @Turbo259 advertising - putting in writing for example an negative action to show they are guilty prior to taking action.
Back
Top