EsArr-17018

[iRRegularity]

Any experiences, anecdote, etc?

 

[sadophyte]

Does this have any other names or a CAS#

 

[player72]

Does this have any other names or a CAS#

If you read out loud it will click - CAS two one three four six zero two dash four five dash zero

 

[sadophyte]

Ohhhh its obvious now lol
Have not tried it but heres a summary of relevant pharmacological information but i have yet to encounter user reports anywhere:

its known in NPS researxh for its relative safety, shown to have a wide window of therapy, and high mu selectivity with an EC50 of 97 nM. green flags for me, greener flag is appearently an ability to reverse morphine tolerence, i could use that but rn im nodding of like 30mg so im pretty light weight on the morpho.

Unlike tripple receptor partial or full agonism esar enduces mu Receptor Phosphorylation and Dephosphorylation equipotent to buprenorphine (at the mu site)

one study showed increase in motor activity in mice, it could be a stimulating kind of low, my favorite dope is the get up and go dope.

Im pretty loaded on a morphine30 and 50+mg codine so i hope this was coherent or helpful

 

[iRRegularity]

Ohhhh its obvious now lol
Have not tried it but heres a summary of relevant pharmacological information but i have yet to encounter user reports anywhere:

its known in NPS researxh for its relative safety, shown to have a wide window of therapy, and high mu selectivity with an EC50 of 97 nM. green flags for me, greener flag is appearently an ability to reverse morphine tolerence, i could use that but rn im nodding of like 30mg so im pretty light weight on the morpho.

Unlike tripple receptor partial or full agonism esar enduces mu Receptor Phosphorylation and Dephosphorylation equipotent to buprenorphine (at the mu site)

one study showed increase in motor activity in mice, it could be a stimulating kind of low, my favorite dope is the get up and go dope.

Im pretty loaded on a morphine30 and 50+mg codine so i hope this was coherent or helpful

Maybe my attempt to be less directly searchable on the Göôg was unnecessary and just confused other people too and that's why it took so long to get a response lmao.

I've seen a couple people compare it to bupr3n0rphïne, which I'm doing a quick taper of right now. I bought an amount because it was new, exciting, and seemed like it might even aid in the exit process.

Just not really sure how to approach it. I'm with you on the get-up-and-go thing, so I'm thinking I'll just give it a shot and do the whole low and slow thing and hope for the best over a few days. As long as it helps with wds it's a winner for me lol.

Oh and yes, your response was helpful and greatly appreciated.

 

[ethereal]

Ohhhh its obvious now lol
Have not tried it but heres a summary of relevant pharmacological information but i have yet to encounter user reports anywhere:

its known in NPS researxh for its relative safety, shown to have a wide window of therapy, and high mu selectivity with an EC50 of 97 nM. green flags for me, greener flag is appearently an ability to reverse morphine tolerence, i could use that but rn im nodding of like 30mg so im pretty light weight on the morpho.

Unlike tripple receptor partial or full agonism esar enduces mu Receptor Phosphorylation and Dephosphorylation equipotent to buprenorphine (at the mu site)

one study showed increase in motor activity in mice, it could be a stimulating kind of low, my favorite dope is the get up and go dope.

Im pretty loaded on a morphine30 and 50+mg codine so i hope this was coherent or helpful

What's a typical analgesic dose of this stuff for a large adult male? Just curious as I have never tried it.......

 

[iRRegularity]

What's a typical analgesic dose of this stuff for a large adult male? Just curious as I have never tried it.......

Iirc, the Internet suggests that it is roughly equipotent to m0rphïñē, so if you use something like "mg per kg m0rphïñē" as search criteria you would get a rough idea. An example result of said search would be a table on the NIH dot gov website with the following subdirectory/page: /books/NBK546195/table/ch2.tab1/

(I'm not sure if links other than vendors posting their menus are allowed and I just woke up so I don't have the will to go read the rules right now lol.)

That table has analgesic dosage recommendations for many medically applicable analgesics by weight via different ROAs. Keep in mind that this is an RC and some effects differ significantly from m0rphïñē, though.