EsArr-17018

Ohhhh its obvious now lol
Have not tried it but heres a summary of relevant pharmacological information but i have yet to encounter user reports anywhere:

its known in NPS researxh for its relative safety, shown to have a wide window of therapy, and high mu selectivity with an EC50 of 97 nM. green flags for me, greener flag is appearently an ability to reverse morphine tolerence, i could use that but rn im nodding of like 30mg so im pretty light weight on the morpho.

Unlike tripple receptor partial or full agonism esar enduces mu Receptor Phosphorylation and Dephosphorylation equipotent to buprenorphine (at the mu site)

one study showed increase in motor activity in mice, it could be a stimulating kind of low, my favorite dope is the get up and go dope.

Im pretty loaded on a morphine30 and 50+mg codine so i hope this was coherent or helpful
 
Ohhhh its obvious now lol
Have not tried it but heres a summary of relevant pharmacological information but i have yet to encounter user reports anywhere:

its known in NPS researxh for its relative safety, shown to have a wide window of therapy, and high mu selectivity with an EC50 of 97 nM. green flags for me, greener flag is appearently an ability to reverse morphine tolerence, i could use that but rn im nodding of like 30mg so im pretty light weight on the morpho.

Unlike tripple receptor partial or full agonism esar enduces mu Receptor Phosphorylation and Dephosphorylation equipotent to buprenorphine (at the mu site)

one study showed increase in motor activity in mice, it could be a stimulating kind of low, my favorite dope is the get up and go dope.

Im pretty loaded on a morphine30 and 50+mg codine so i hope this was coherent or helpful
Maybe my attempt to be less directly searchable on the Göôg was unnecessary and just confused other people too and that's why it took so long to get a response lmao.

I've seen a couple people compare it to bupr3n0rphïne, which I'm doing a quick taper of right now. I bought an amount because it was new, exciting, and seemed like it might even aid in the exit process.

Just not really sure how to approach it. I'm with you on the get-up-and-go thing, so I'm thinking I'll just give it a shot and do the whole low and slow thing and hope for the best over a few days. As long as it helps with wds it's a winner for me lol.

Oh and yes, your response was helpful and greatly appreciated. 🙏🏾
 
Ohhhh its obvious now lol
Have not tried it but heres a summary of relevant pharmacological information but i have yet to encounter user reports anywhere:

its known in NPS researxh for its relative safety, shown to have a wide window of therapy, and high mu selectivity with an EC50 of 97 nM. green flags for me, greener flag is appearently an ability to reverse morphine tolerence, i could use that but rn im nodding of like 30mg so im pretty light weight on the morpho.

Unlike tripple receptor partial or full agonism esar enduces mu Receptor Phosphorylation and Dephosphorylation equipotent to buprenorphine (at the mu site)

one study showed increase in motor activity in mice, it could be a stimulating kind of low, my favorite dope is the get up and go dope.

Im pretty loaded on a morphine30 and 50+mg codine so i hope this was coherent or helpful

What's a typical analgesic dose of this stuff for a large adult male? Just curious as I have never tried it.......
 
What's a typical analgesic dose of this stuff for a large adult male? Just curious as I have never tried it.......
Iirc, the Internet suggests that it is roughly equipotent to m0rphïñē, so if you use something like "mg per kg m0rphïñē" as search criteria you would get a rough idea. An example result of said search would be a table on the NIH dot gov website with the following subdirectory/page: /books/NBK546195/table/ch2.tab1/

(I'm not sure if links other than vendors posting their menus are allowed and I just woke up so I don't have the will to go read the rules right now lol.)

That table has analgesic dosage recommendations for many medically applicable analgesics by weight via different ROAs. Keep in mind that this is an RC and some effects differ significantly from m0rphïñē, though.
 
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  1. xenxra @ xenxra: @WTF7218 it may as well be that way with how little effort some of the people on here make to find information that's exactly where you would expect it to be.
  2. ontovzik @ ontovzik: When I had long term shingles, lasting two months. All he could give me was a 10 day supply of dilaudid. He looked at the ground while we were talking about it. I could tell he was ashamed but it was the legislature and the governor that tied his hands. He was very upset that non-medical political people, the media, and the scared public were controlling how he treated his patients. Someday those people will need meds and a hospital bed and they will be gone.
  3. ontovzik @ ontovzik: I had a great doctor, he had the true gift of a healer and he stayed on top of all the science. He straight up told me that for many people opiods work for managing short and long term pain.
  4. ontovzik @ ontovzik: He peed it in the snow in my backyard.
  5. WTF7218 @ WTF7218: @xenxra 😆😂. Yes, but only a few brave souls will ever find the number. You must first order a Dirty Shirley from the bartender. Then you must discreetly take the cocktail napkin from under your drink and unfold it. There you will find the map to the location of the phone number, and clues to decipher the code that it is written in.
  6. xenxra @ xenxra: he left his phone number scribbled in a stall at the pub three blocks down
  7. N @ NYStateofMind: @Alkazar I would try one of those easy online ones .. reddit gives useful info about that
  8. Alkazar @ Alkazar: @NYStateofMind I dont really have a history of abusing things, my docotr is just really stingy. I am thinking of switching.
  9. C @ Cheesus: Thanks xenxra
  10. xenxra @ xenxra: @Cheesus yeah, use snote
  11. P @ psychedpsych: Trump is cracking down….
  12. P @ psychedpsych: Hackers are the scum of the earth
  13. N @ NYStateofMind: so it was easy bc of my history
  14. N @ NYStateofMind: I didnt really tell him but he knew I needed a new script since my dr went to jail
  15. N @ NYStateofMind: @xenxra I was on Adderall since 15 years ago so my dr prescribed that w no problems and then when I lost my best friend my doctor rxed the valiums but
  16. C @ Cheesus: Temp.pm down for anyone else?
  17. xenxra @ xenxra: @NYStateofMind my doctor's have always been pretty open minded if i can actually come in and explain the pharmacological action of the drugs im seeking instead of just telling them why i think i should be prescribed. the only time it didn't work out for me is when i was trying pharmaceuticals for depression ten years ago and suggested they let me try testosterone instead (turns out i was hypogonadal so they made a mistake denying my request at face value)
  18. T @ Testisthebest: Even down here in Florida when the pill mill docs all switched over to Suboxone and/or retired you can still find some pretty liberal docs but you gotta know what to look for. Mine does "pain management, detox, anxiety,etc. And no insurance. My doc writes me 60 5mg Valium, 14 2mg Xanax and asked if I had ever tried adderal to get more focus at work as I told him I run my own business.
  19. N @ NYStateofMind: @Alkazar do they know your history? Like I dont tell my doctor anything about myself except what they need to know,...I was able to get my dr to rx the highest dose of adderall along with valiums ..... if they dont know your history or there is no history I would just come out and ask what is the reason for their mistreatment.... they have no problem billing your insurance or taking a payment for the visit
  20. T @ Turbo259: @Layne_Cobain Thank you fam
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