MDMA replacement RCs and organic chem question

1

1rocketcycle

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Jan 27, 2020
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I've seen some recipes for blends that can sub for MDMA with mixed results and wanted to share my thoughts and see what you more-experienced people would suggest, since I'm new at this. I'm a neuroscientist with some chemistry training, so I'm not totally clueless about the mechanisms involved - I just haven't directly experienced almost everything (2 or 3 MDMA, 1 5-MAPB, 1 5-MAPB/4-AcO-DMT combo) and I know there's a lot of inter-person variation.

So, I'm fine-tuning a blend to attempt to replace MDMA as closely as possible, since I moved to an area where the opioid crisis hit so badly that the authorities are ludicrously vigilant 🤬. I got a pack of good 5-MAPB from Smokey's and 4-aco-DMT from a darknet vendor, so I know things can get through, but two shipments of real MDMA - 1 pill, 1 rock/powder - failed even with reships. I may be able to set up a POB in California (I visit every couple months for work) but it'd be a whole lot easier and less risky to come up with a replacement blend.

After lots of reading at Erowid and Psychonaut Wiki I decided to try a combo of 4-FA, 5-MAPB, and 4-AcO-DiPT. Then finding out that 4FA is long gone, went with 4-FMA. I get the empathogenic warm fuzzies from 5-MAPB (feels very sensory-serotonergic, at least with temp and tactile responses). Haven't tried 4-FMA, but I didn't want too much stimulation from it, more the euphoria/entactogen feel, and it sounded like the 2- and 3-F versions were much more straight-amphetamine-like. Finally, I want the tingly mild psychedelics of 4-AcO-DiPT and (from the user experiences) the increased libido/sexual sensation that seem to go with it. 👩‍❤️‍👨

So, does this sound like a reasonable substitute for MDMA? Any suggestions on ratio, timing, etc.? I know the APB is a little slower in its activity than the others, but with only about a 15 minute difference, I could probably have a good 2-hr or so overlapped peak even if they're all in one cap.

Lastly, for the chemists in the audience - 5-MAPB seems to be about as close structurally to MDMA that you can get, but the missing O that turns dimethoxy- into benzofuran seems to be pretty important in terms of structure-activity relationship. Looking at the structures, size and shape are very similar, so I'm guessing it's an electrostatic interaction that changes the Ki values. What I'm wondering is if you could do a relatively simple Friedel-Crafts acylation or similar reaction with the 5-MAPB, and attack the furan to attach an electron donor (O is a donor, right?), say a keto or carboxyl/hydroxyl group, in the position where the second O would normally be in MDMA?  If it's possible, do you think it'd be as close or closer to MDMA as 5-MAPB in experience? And has it been tried already and I just didn't know? 😉 

 
I personally like 5-APB the most, but I'm also a big fan of 4-FA although I don't think it's as similar to MDMA. I imagine 4-FA mixed with 5-MAPB would be close.

 
borax formula. 5 mapb for roll, 2 fma for amp and 3 ho or 3 aco met for the magic. 3 ho met is great by itself btw. not a roll but a fun trip with no anxiety 

 
I've personally experimented with the Borax Combo.  You can look it up on Reddit.  I really can't tell the difference between this and real mdma to be honest.

 
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  2. B @ bigblueallda: @drjimmy1964 lol I am actually surprised it is a real ID. I needed those documents because my license had been expired for over a year and I had to start all over. Nothing was in the system. It was a huge mess. I had no clue I was signing up for Real ID. They asked me for the exact same documents that I needed for a State ID Card.
  3. S @ soupson: bless your heart buddy. no sense of grammar or proper insults/jokes. you need this place in ways i can’t comprehend
  4. drjimmy1964 @ drjimmy1964: Sweet Ol' Me asked about Real ID, Stoup. Are you responsive to emails ? LMAO
  5. drjimmy1964 @ drjimmy1964: I smell some Stoup. Is Stoup's on ?
  6. drjimmy1964 @ drjimmy1964: @bigblueallda You win. I am lost. Thought you were surprised your license was a Real ID, now you say you provided those items.
  7. drjimmy1964 @ drjimmy1964: @bigblueallda I was under the impression that you'd need all of the points to get a real ID . I'd check it's validity if you're gonna fly domestic any time soon, just to make sure. Not to tell you what to do, sorry -
  8. B @ bigblueallda: @drjimmy1964 In my state to get a Real ID, I need SS card, Birth Certificate and two proofs of residency. Which I am positive I had to provide to get a new ID when it had been expired.
  9. drjimmy1964 @ drjimmy1964: @Turbo259 advertising - putting in writing for example an negative action to show they are guilty prior to taking action.
  10. B @ bigblueallda: I haven't flown in an airplane in 20 years lol. Can't recall the last government building I have been in either. According to the symbol it tells me I should have on my ID to make it a Real ID I do have one in my state
  11. Gracie5 @ Gracie5: Hey @CuCeltic99!
  12. drjimmy1964 @ drjimmy1964: @Turbo259 advertising - putting in writing for example an negative action to show they are guilty prior to taking action.
  13. drjimmy1964 @ drjimmy1964: @bigblueallda are you sure you have a Real ID ? I mean , they really want 6 points of proof and 1 for your addy and 1 for your SSN. Did you maybe get it done and forgot and flew out of the country or something ?
  14. drjimmy1964 @ drjimmy1964: @bigblueallda are you sure you have a Real ID ? I mean , they really want 6 points of proof and 1 for your addy and 1 for your SSN. Did you maybe get it done and forgot and flew out of the country or something ?
  15. S @ soupson: did anyone ask about real id or is sweet ol jimmy just rambling
  16. T @ Turbo259: @drjimmy1964 what did you mean by advertise? not gettin the verbiage, DM works if anything, just didnt understand
  17. B @ bigblueallda: {Visit your local Driver Service Bureau with the necessary documents: original birth certificate, Social Security card, and two proofs of your state's residency. } I definitely provided this when I had to get a new ID when i let mine go expired too long maybe I unknowingly got one but I think it is pretty standard here.
  18. B @ bigblueallda: Well it was a state id renewal. Before that there was a mixup and I had lost my birth certficate and social security number. After a couple of weeks and finally getting several documents in order I was able to get a state ID. It had been expired previously for a little too long and they wanted all kinds of proof. It was a mess. But nah I looked up what to look for an my state's ID to see if it is a Real Id or not and my card as the symbol it is supposed to have. I'll take a closer look though
  19. drjimmy1964 @ drjimmy1964: @bigblueallda are you sure you have a Real ID ? I mean , they really want 6 points of proof and 1 for your addy and 1 for your SSN. Did you maybe get it done and forgot and flew out of the country or something ?
  20. drjimmy1964 @ drjimmy1964: Actually it says "Not For Real ID Purposes". That is my 2022 renewal of my 2018 picture ID. I am not due till 2026 and I am sure they will make me go in since my pic would be 8 years old - they used to make you go in in my state for aging when I was younger, then went paper - then back to picture ( I think 9/11 to blame for that ) but relaxed it.
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