N-acetylcysteine (NAC) is one of the most widely used emergency interventions for tylenol overdose; It prevents liver damage and is given in the ER. Studies show oral supplementation is also effective at preventing liver damage from tylenol toxicity. It is available OTC as a supplement, and I've tried several times over the years to use it to protect my liver from all the tylenol but it seems to upset my stomach. Anyone had any luck using NAC? I have a relative who uses it daily (she has liver disease) and swears by it. Last night I got super-paranoid that I had poisened myself with tylenol after taking about 2,000mg over the course of the day (in Vicodin); thinking of trying it again.
Paracetamol self-poisoning: when oral N-acetylcysteine saves life? a case report.
Benlamkaddem S1, Iken I2, Houari N1, Elbouazzaoui A1, Boukatta B1, Sbai H1, Achour S2, Kanjaa N1.
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Abstract
Paracetamol is the most widely drug involved in accidental paediatric exposures and deliberate self-poisoning cases because of its availability. N-acetyl cystein is the main treatment for this poisoning. We report a case of a 24-year-old Arab female who has deliberately ingested 100 tablets of 500 mg paracetamol each (50g). Her first examination was normal. She has received oral N-acetyl cystein (NAC) 6 hours after the ingestion. Serum paracetamol level done 18 hours post ingestion was 900 mg/l. On review the next days, she did not develop any symptoms of liver failure. However, due to the massive paracetamol ingestion associated with high serum paracetamol levels, oral NAC was continued for 3 days. The patient was discharged well on the fifth day of hospitalization. Our patient has ingested one of the highest paracetamol overdose (50g) with the highest paracetamol blood levels ever reported in medical literature. She was treated, six hours after ingestion, with oral NAC for 3 days without any side effects
Paracetamol self-poisoning: when oral N-acetylcysteine saves life? a case report.
Benlamkaddem S1, Iken I2, Houari N1, Elbouazzaoui A1, Boukatta B1, Sbai H1, Achour S2, Kanjaa N1.
Author information
Abstract
Paracetamol is the most widely drug involved in accidental paediatric exposures and deliberate self-poisoning cases because of its availability. N-acetyl cystein is the main treatment for this poisoning. We report a case of a 24-year-old Arab female who has deliberately ingested 100 tablets of 500 mg paracetamol each (50g). Her first examination was normal. She has received oral N-acetyl cystein (NAC) 6 hours after the ingestion. Serum paracetamol level done 18 hours post ingestion was 900 mg/l. On review the next days, she did not develop any symptoms of liver failure. However, due to the massive paracetamol ingestion associated with high serum paracetamol levels, oral NAC was continued for 3 days. The patient was discharged well on the fifth day of hospitalization. Our patient has ingested one of the highest paracetamol overdose (50g) with the highest paracetamol blood levels ever reported in medical literature. She was treated, six hours after ingestion, with oral NAC for 3 days without any side effects