NAC to counteract tylenol toxicity

Roxyanne

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N-acetylcysteine (NAC) is one of the most widely used emergency interventions for tylenol overdose;  It prevents liver damage and is given in the ER.  Studies show oral supplementation is also effective at preventing liver damage from tylenol toxicity.   It is available OTC as a supplement, and  I've tried several times over the years to use it to protect my liver from all the tylenol but it seems to upset my stomach.   Anyone had any luck using NAC?  I have a relative who uses it daily (she has liver disease) and swears by it.     Last night I got super-paranoid that I had poisened myself with tylenol after taking about 2,000mg over the course of the day (in Vicodin);  thinking of trying it again.


Paracetamol self-poisoning: when oral N-acetylcysteine saves life? a case report.


Benlamkaddem S1, Iken I2, Houari N1, Elbouazzaoui A1, Boukatta B1, Sbai H1, Achour S2, Kanjaa N1.

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Abstract



Paracetamol is the most widely drug involved in accidental paediatric exposures and deliberate self-poisoning cases because of its availability. N-acetyl cystein is the main treatment for this poisoning. We report a case of a 24-year-old Arab female who has deliberately ingested 100 tablets of 500 mg paracetamol each (50g). Her first examination was normal. She has received oral N-acetyl cystein (NAC) 6 hours after the ingestion. Serum paracetamol level done 18 hours post ingestion was 900 mg/l. On review the next days, she did not develop any symptoms of liver failure. However, due to the massive paracetamol ingestion associated with high serum paracetamol levels, oral NAC was continued for 3 days. The patient was discharged well on the fifth day of hospitalization. Our patient has ingested one of the highest paracetamol overdose (50g) with the highest paracetamol blood levels ever reported in medical literature. She was treated, six hours after ingestion, with oral NAC for 3 days without any side effects



 
I haven’t used nac ir liver protection but this is very interesting information and I want to thank you for posting it.

 
Yes, I am heterozygous for the C677T polymorphism in the MTHFR Gene, and my liver does a very poor job of detoxing many substances, Tylenol being one, which has led to non alcoholic fatty liver disease. My functional medicine/internist has prescribed NAC to me. I use a powder. It’s 1,200 mg, and I use one scoop (500 g) daily. I also cannot consume folic acid, and have to supplement with folate. Several years ago I had extremely toxic amounts of B12 in my blood, and that, along with so many problems metabolizing different classes of medications, led to having the genetic testing.

 
Another clue to this was reduced bile flow- doctors really only seem to care if one has too much bile, but reduced amounts are a sign your liver isn’t properly detoxing. That leads to clogged arteries and increased risk for heart disease.

I also use milk thistle. It’s a supplement used for liver detoxification. My liver enzymes were extremely high almost 2 years ago and my doctor suspected Hepatitis, but that wasn’t the case, and it happened other times before starting these supplements. I’m not supposed to use Tylenol at all.

I have to say it’s late, and I’m tired, so some of my terminology/vocabulary isn’t 100%, but hopefully this answers the question somewhat. I’ve had other genetic testing, also, and many weird problems nutritionally and otherwise.

 
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Started using Jarrow formulas NAC-sustain (its a time-released version that breaks down in your small intestine rather than stomach) and so far no side effects.  It says to take on a empty stomach with fruit juice.  I've been taking it with water and alittle fruit.   The regular NAC gave me bad indigestion, but this formula doesnt.   so far so good!

 
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  1. B @ bigblueallda: @drjimmy1964 lol I am actually surprised it is a real ID. I needed those documents because my license had been expired for over a year and I had to start all over. Nothing was in the system. It was a huge mess. I had no clue I was signing up for Real ID. They asked me for the exact same documents that I needed for a State ID Card.
  2. P @ psychedpsych: Whew, long night of giving rides. How's y'all's night go? Im debating driving for 2 more rides to hit my goal, should I keep going?
  3. S @ soupson: bless your heart buddy. no sense of grammar or proper insults/jokes. you need this place in ways i can’t comprehend
  4. drjimmy1964 @ drjimmy1964: Sweet Ol' Me asked about Real ID, Stoup. Are you responsive to emails ? LMAO
  5. drjimmy1964 @ drjimmy1964: I smell some Stoup. Is Stoup's on ?
  6. drjimmy1964 @ drjimmy1964: @bigblueallda You win. I am lost. Thought you were surprised your license was a Real ID, now you say you provided those items.
  7. drjimmy1964 @ drjimmy1964: @bigblueallda I was under the impression that you'd need all of the points to get a real ID . I'd check it's validity if you're gonna fly domestic any time soon, just to make sure. Not to tell you what to do, sorry -
  8. B @ bigblueallda: @drjimmy1964 In my state to get a Real ID, I need SS card, Birth Certificate and two proofs of residency. Which I am positive I had to provide to get a new ID when it had been expired.
  9. drjimmy1964 @ drjimmy1964: @Turbo259 advertising - putting in writing for example an negative action to show they are guilty prior to taking action.
  10. B @ bigblueallda: I haven't flown in an airplane in 20 years lol. Can't recall the last government building I have been in either. According to the symbol it tells me I should have on my ID to make it a Real ID I do have one in my state
  11. Gracie5 @ Gracie5: Hey @CuCeltic99!
  12. drjimmy1964 @ drjimmy1964: @Turbo259 advertising - putting in writing for example an negative action to show they are guilty prior to taking action.
  13. drjimmy1964 @ drjimmy1964: @bigblueallda are you sure you have a Real ID ? I mean , they really want 6 points of proof and 1 for your addy and 1 for your SSN. Did you maybe get it done and forgot and flew out of the country or something ?
  14. drjimmy1964 @ drjimmy1964: @bigblueallda are you sure you have a Real ID ? I mean , they really want 6 points of proof and 1 for your addy and 1 for your SSN. Did you maybe get it done and forgot and flew out of the country or something ?
  15. S @ soupson: did anyone ask about real id or is sweet ol jimmy just rambling
  16. T @ Turbo259: @drjimmy1964 what did you mean by advertise? not gettin the verbiage, DM works if anything, just didnt understand
  17. B @ bigblueallda: {Visit your local Driver Service Bureau with the necessary documents: original birth certificate, Social Security card, and two proofs of your state's residency. } I definitely provided this when I had to get a new ID when i let mine go expired too long maybe I unknowingly got one but I think it is pretty standard here.
  18. B @ bigblueallda: Well it was a state id renewal. Before that there was a mixup and I had lost my birth certficate and social security number. After a couple of weeks and finally getting several documents in order I was able to get a state ID. It had been expired previously for a little too long and they wanted all kinds of proof. It was a mess. But nah I looked up what to look for an my state's ID to see if it is a Real Id or not and my card as the symbol it is supposed to have. I'll take a closer look though
  19. drjimmy1964 @ drjimmy1964: @bigblueallda are you sure you have a Real ID ? I mean , they really want 6 points of proof and 1 for your addy and 1 for your SSN. Did you maybe get it done and forgot and flew out of the country or something ?
  20. drjimmy1964 @ drjimmy1964: Actually it says "Not For Real ID Purposes". That is my 2022 renewal of my 2018 picture ID. I am not due till 2026 and I am sure they will make me go in since my pic would be 8 years old - they used to make you go in in my state for aging when I was younger, then went paper - then back to picture ( I think 9/11 to blame for that ) but relaxed it.
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