Orexin Receptor Antagonists for Sleep

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A lot of sources say this new class of drug will be very useful. I am not so sure. Belsomra which seems to be the only one out at the moment is getting some bad reviews.

Perhaps there will be another however in this class that helps, it sure would be good to switch from using some of the more old-school heavy stuff (when I need it).

Here is a good article on the future of sleep medication: http://mentalhealthdaily.com/2015/06/30/new-sleeping-pills-2015-orexin-receptor-antagonists/

 
Thanks for the article. I have never found a sleeping pill that really works well. I will be interested to see how these are received.

Although not related to the article, I am starting to suspect that my mattress is adding to my sleep deprivation. I'm sleeping better in hotel rooms.

 
It would be nice to have a benzo alternative so we could take long breaks from benzos and reduce tolerance. With chronic severe insomnia benzos are the only drug that help me fall asleep and i call sleep initiators and things like antihistamines i find ineffective on their own but when combined with benzos help me to sustain my sleep and help me sleep deeper.

My insomnia started after a couple of nasty viral infections close together 14 yrs ago.

 
We will see when this Belsomra gets going. It has had a lot of bad review so far. But apparently works quite well if you dose 40mg. My question is what are the side effects. Certain sleepers I don't bother with because their side effects are about the same as not sleeping at all!

The idea with these new ones is that they just target a smaller part of the brain instead of shutting down your whole cns.

 
Last edited:
JoeBloggs said:
We will see when this Belsomra gets going. It has had a lot of bad review so far. But apparently works quite well if you dose 40mg. My question is what are the side effects. Certain sleepers I don't bother with because their side effects are about the same as not sleeping at all!

The idea with these new ones is that they just target a smaller part of the brain instead of shutting down your whole cns.
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The cost is also a big factor with belsomra. 

 
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  2. M @ meepmoopmeep: as an A&M fan I’m content with us missing the SECCG for that reason. Georgia about to fuck Alabama up
  3. D @ drdrizzy13: Yeah I agree if bama loses I think they are out. That would be 3 losses. I don't see a 3 loss team getting in this year.
  4. L @ Layne_Cobain: Yeah that’s why sark was pleading his case about that Texas shouldn’t be punished for scheduling a non conference game against the best team and losing if they hadn’t done that they’d probably be in but oh well way it goes there’s always gonna be a few teams who get robbed or feel they got robbed even with a 12 team playofff…if bama loses to Georgia I’d think they’d be out but who knows
  5. D @ drdrizzy13: Alabama also lost to Florida State pretty bad. Whom Florida beat. I just think if they didn't decide to play ohio state the first game. They would be in with 2 losses instead of Alabama.
  6. M @ meepmoopmeep: @drdrizzy13 Texas lost to Florida of all teams, they weren’t heading for the playoffs anyways imo. At least not this year
  7. D @ drdrizzy13: Texas is offically out of the playoffs they didn't make the top 12. I do wish they were in it. They showed up against Texas AM. But there fatal flaw was scheduling Ohio State for their opening. Which would have been great if they won but they are a 3 loss team now.
  8. L @ Layne_Cobain: Yeah idk about arch I could see him staying with Sark for another year but if he plays rly well in the playoff who knows that is if they get in
  9. D @ drdrizzy13: Man a lot of Saints fan want Arch but I think he said he is playing another year. I would take him probably. But if Texas AM QB comes out or Ohio State's I think you gotta take one if your picking top 2.
  10. L @ Layne_Cobain: Is the qb class supposed to be stacked or thin for draft in April I follow college ball but I can’t think right now I think there’s def at least a few high potential qb declaring
  11. D @ drdrizzy13: Right now I believe we pick 2nd. ATM.
  12. D @ drdrizzy13: At first I figured he might be able to do something but our position players suck. We are playing a rookie QB. O-line sucks. It needs to be blown up. I hope we tank for the first pick
  13. L @ Layne_Cobain: Hopefully you guys maybe find a solid qb option in the draft you should end up with a very good pick
  14. L @ Layne_Cobain: Yeah dude Moore def does not seem like the guy for yall need to clean house
  15. D @ drdrizzy13: I should say our receivers suck
  16. D @ drdrizzy13: AK is hurt. Our receivers hurt and our starting QB went to college for fucking 6 years. If that tells you something. Also he never completed a complete season in college due to injury. We need a new GM and FAST. And surprisingly Kellen Moore's play calling has been TERRIBLE.
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  18. D @ drdrizzy13: lol trust me you will. We are the worst team in the league. I think we had like 24 yards of offense in the first half last week or one week. I haven't seen it this bad since before Drew Brees was QB.
  19. L @ Layne_Cobain: @drdrizzy13 we should dude but for that very reason I’m worried lol you guys already got us once! Good luck tho buddy
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