xanax and tramadol combo?

Y

yngtxnes

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Apr 7, 2017
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has anyone tried the two together? i have both right now and am curious what the effects would be like or if its just a waste of one of them because the other might overshadow the others effects? and idk about the doses i would use. if anyone has experience with this itd be appreciated

 
Depending on your tolerance, if you do this, keep the dosage low tk begin with, main danger is depressing your central nervous system. Be cautious in any case. 

 
@yngtxnes i have been taking tramz for about 15 years. First bought OTC whilst working in India and have continued to use them (sadly) on a daily basis since then. I tend to dose the tramz early morning 200mg single dose. Some times I reduce to 150mg and to be honest the effect is still as good. I enjoy the dual effects of the chilled out feel but with an energy like boost. For me onset is about 30-45 minutes. 6 hours duration max effect at about 120 minutes.  I use Barzz very infrequently, I find 1.5mg of a bar drops me like a brick. There is always a 10 hour gap in between the doses though. Tramz through the hepatic system is metabolized through the CYP2D6 enzyme. Xanax through the CYP3A4 & CYP3A5 enzymes.

Personally I use this info to tell me not to worry too much about serotonin syndrome, but I am no Pharma genious or Cytochrome expert.

As PT very rightly states depression of the CNS is always going to carry a risk. Age / weight/ Dosage / LFT's are all things to be taken into account.

If you have no tolerance for either product go much lower than what I use above. Way lower...

Always take caution, watch the dose and timings...

Peace and goodwill..

 
Last edited by a moderator:
As @PTFC said, start low and see what happens. As a general matter, you should always google X interactions with Y before combining anything. Tramz have a potentially nasty interaction with a variety of drugs, though I think benz0s are okay.

 
Yep, Tramzz and other opi8's or synthetic opii8's that bind to the same receptors could bring on Serotonin Syndrome. As @HeirCroc1 states. Google with multiple sources of information will corroborate and allow you to use wisely.

 
Also, Adderall lowers your seizure threshold and so do tramz. So there's that too. Definitely don't mix those two if you have a history of seizures.

 
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