You all should really try Bretazenil

i got some and from my research couldn't tell what it was. zero normal effects from others in same class.

when testing 20x normal dose as last chance to get relevant data the effects were almost like a disso where everything reverberated.

was really interested in bretazenil's potential as something to wean one off this class
 
RClikeITS1999 said:
It's been a great anti anxiety for me. Great sleep.
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I'm going to venture a guess that you aren't physically dependent on benzodiazepines. I am, and even though I knew it was a partial agonist, there were contradictory studies on whether or not it precipitated withdrawal in dependent individuals, so I decided to give it a shot.

Thank God it had a short half-life (literature says 1.5 hours), because for about 5 hours after taking it, I felt like I was on day 3 CT. And it has a crazy high binding affinity like naloxone, meaning the only way to get out of WDs is to wait it out or take an insanely high dose of a full BZD, which can easily be lethal.
 
TheDude1234 said:
I'm going to venture a guess that you aren't physically dependent on benzodiazepines. I am, and even though I knew it was a partial agonist, there were contradictory studies on whether or not it precipitated withdrawal in dependent individuals, so I decided to give it a shot.

Thank God it had a short half-life (literature says 1.5 hours), because for about 5 hours after taking it, I felt like I was on day 3 CT. And it has a crazy high binding affinity like naloxone, meaning the only way to get out of WDs is to wait it out or take an insanely high dose of a full BZD, which can easily be lethal.
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very curious if this played a part in my very very weird experiences with it. did not all ALL feel like PW, though.
 
That's interesting. From what I've seen in my own studies of the literature is that it doesn't necessarily cause precipitated withdrawal in all dependent people. I'm super curious why it would in some cases but not all
 
I wish I could feel brave enough & have the free time to give it a go. It sounds promising in ways, but the risks seem to outweigh the benefits to me rn. It would be great if it worked well as a taper, but most things I’ve read make it seem like it with just give me PWD.
 
depending on which receptor sites the mags one subscribes to and the level of subscription might determine if pw happens? studies i've read use it compared it to standard mags while less widely spread ones that target diff audiences could have different effects?

i'm still really really curious wtf mag i might even have. ideas for best place to send copypasta to for editor analysis?
 
Per Wikipedia: Bretazenil has a more broad spectrum of action than traditional benzodiazepines as it has been shown to have low affinity binding to α4 and α6 GABAA receptors in addition to acting on α1, α2, α3 and α5 subunits which traditional benzodiazepine drugs work on. The partial agonist imidazenil does not, however, act at these subunits.

On sleep:

Bretazenil alters the sleep EEG profile and causes a reduction in cortisol secretion and increases significantly the release of prolactin.[24] Bretazenil has effective hypnotic properties but impairs cognitive ability in humans. Bretazenil causes a reduction in the number of movements between sleep stages and delays movement into REM sleep. At a dosage of 0.5 mg of bretazenil REM sleep is decreased and stage 2 sleep is lengthened.[25]
 
I am actually wondering if some place like clearnet leb site Ambeed.com would distribute this as it is totally uncontrolled.

They offer

$29.00/5g and https://www.ambeed.com/bretazenil.html​


which would be .0058 per dose.

Ambeed.com let me set up an account but I do not know if they wil sell to individuals without an LLC or a Corp. Ill email them now and get back to you.
 
I have an update to my original post regarding PWD. I'm on like day 10 of CT due to supply issues. Been feeling all the expected symptoms.

Then I remembered I had a sample of it sitting in the drawer. I did volumetric this time, took a much more reasonable dose of roughly 1 mg and 30 minutes later I felt a significant reduction in anxiety, which has been so crippling I've barely left my house. Another 1 mg later, and my appetite has returned. I actually feel like I want to eat and not have to force myself.

So I've definitely changed my mind about this one. Definitely very handy when you're between a rock and a hard place.
 
RClikeITS1999 said:
I am actually wondering if some place like clearnet leb site Ambeed.com would distribute this as it is totally uncontrolled.

They offer

$29.00/5g and https://www.ambeed.com/bretazenil.html​


which would be .0058 per dose.

Ambeed.com let me set up an account but I do not know if they wil sell to individuals without an LLC or a Corp. Ill email them now and get back to you.
Click to expand...
Hi, did you find out about this?
 
RClikeITS1999 said:
I am actually wondering if some place like clearnet leb site Ambeed.com would distribute this as it is totally uncontrolled.

They offer

$29.00/5g and https://www.ambeed.com/bretazenil.html​


which would be .0058 per dose.

Ambeed.com let me set up an account but I do not know if they wil sell to individuals without an LLC or a Corp. Ill email them now and get back to you.
Click to expand...
Also curious if they responded to your email.
 
So i emailed Ambeed, and they have a policy in which they only interact (and process purchase orders) for customers with a business email. I've been needing to make a website for something anyways, so once that's done I'll reach out to them again. If anybody else has a business email address or their own domain let me know what they say. I'd be down to throw in for at least 5g for my GC/MS experiment
 
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  2. B @ bigblueallda: @drjimmy1964 lol I am actually surprised it is a real ID. I needed those documents because my license had been expired for over a year and I had to start all over. Nothing was in the system. It was a huge mess. I had no clue I was signing up for Real ID. They asked me for the exact same documents that I needed for a State ID Card.
  3. S @ soupson: bless your heart buddy. no sense of grammar or proper insults/jokes. you need this place in ways i can’t comprehend
  4. drjimmy1964 @ drjimmy1964: Sweet Ol' Me asked about Real ID, Stoup. Are you responsive to emails ? LMAO
  5. drjimmy1964 @ drjimmy1964: I smell some Stoup. Is Stoup's on ?
  6. drjimmy1964 @ drjimmy1964: @bigblueallda You win. I am lost. Thought you were surprised your license was a Real ID, now you say you provided those items.
  7. drjimmy1964 @ drjimmy1964: @bigblueallda I was under the impression that you'd need all of the points to get a real ID . I'd check it's validity if you're gonna fly domestic any time soon, just to make sure. Not to tell you what to do, sorry -
  8. B @ bigblueallda: @drjimmy1964 In my state to get a Real ID, I need SS card, Birth Certificate and two proofs of residency. Which I am positive I had to provide to get a new ID when it had been expired.
  9. drjimmy1964 @ drjimmy1964: @Turbo259 advertising - putting in writing for example an negative action to show they are guilty prior to taking action.
  10. B @ bigblueallda: I haven't flown in an airplane in 20 years lol. Can't recall the last government building I have been in either. According to the symbol it tells me I should have on my ID to make it a Real ID I do have one in my state
  11. Gracie5 @ Gracie5: Hey @CuCeltic99!
  12. drjimmy1964 @ drjimmy1964: @Turbo259 advertising - putting in writing for example an negative action to show they are guilty prior to taking action.
  13. drjimmy1964 @ drjimmy1964: @bigblueallda are you sure you have a Real ID ? I mean , they really want 6 points of proof and 1 for your addy and 1 for your SSN. Did you maybe get it done and forgot and flew out of the country or something ?
  14. drjimmy1964 @ drjimmy1964: @bigblueallda are you sure you have a Real ID ? I mean , they really want 6 points of proof and 1 for your addy and 1 for your SSN. Did you maybe get it done and forgot and flew out of the country or something ?
  15. S @ soupson: did anyone ask about real id or is sweet ol jimmy just rambling
  16. T @ Turbo259: @drjimmy1964 what did you mean by advertise? not gettin the verbiage, DM works if anything, just didnt understand
  17. B @ bigblueallda: {Visit your local Driver Service Bureau with the necessary documents: original birth certificate, Social Security card, and two proofs of your state's residency. } I definitely provided this when I had to get a new ID when i let mine go expired too long maybe I unknowingly got one but I think it is pretty standard here.
  18. B @ bigblueallda: Well it was a state id renewal. Before that there was a mixup and I had lost my birth certficate and social security number. After a couple of weeks and finally getting several documents in order I was able to get a state ID. It had been expired previously for a little too long and they wanted all kinds of proof. It was a mess. But nah I looked up what to look for an my state's ID to see if it is a Real Id or not and my card as the symbol it is supposed to have. I'll take a closer look though
  19. drjimmy1964 @ drjimmy1964: @bigblueallda are you sure you have a Real ID ? I mean , they really want 6 points of proof and 1 for your addy and 1 for your SSN. Did you maybe get it done and forgot and flew out of the country or something ?
  20. drjimmy1964 @ drjimmy1964: Actually it says "Not For Real ID Purposes". That is my 2022 renewal of my 2018 picture ID. I am not due till 2026 and I am sure they will make me go in since my pic would be 8 years old - they used to make you go in in my state for aging when I was younger, then went paper - then back to picture ( I think 9/11 to blame for that ) but relaxed it.
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