How to Increase the Potency and Length of Duration of Alprazolam by 3 to 4x

LatsDoodis said:
Why do antihistamines cause increased AUC for Xanax, or how do they affect all the pharmacodynamics? That’s interesting.
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First generation antihistamines reduce Histamine-GABA Cross Talk.

You won’t get the same beneficial response on benzo action from second generation antihistamines like citirizine.
 
knofflebon said:
Ah, that makes more sense, I’d heard acidification (juice) increases excretion of certain stimulants, weakening their potency.
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It’s an enzyme in the skin that inhibits the cyps to potentiate said item, that’s why eating a grapefruit is going ti do nothing. Word of advice there are three major otc items that would inhibit the enzymes CYP3A4 and CYP2D6, the ones you would want to inhibit, these also increase one’ tolerance more than just taking more of said item. There are also inhibitors you may want to look at your medications to see if they are active for said item. Be safe, lesss is always more
 
Just-IN-case said:
CYP3A4 and CYP2D6, the ones you would want to inhibit
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If you are looking to increase length of duration (AUC and Mconc) of your benzo, you want to inhibit CPY3A4, which breaks down the benzo.

If you are taking opeeates you want to inhibit CYP3A4 and promote CPY2D6.

CYP2D6 plays no role in clearing benzos, but if you are taking opeeates you do not want to inhibit CYP2D6.
 
LatsDoodis said:
Smoking will reduce (presumably all) benzodiazepines, according to findings in K-P/n research that suggests 50% reduced blood levels in cigarette smokers. Never heard anything about the coffee. Just causes some ph changes or is it enzymatic as well? Why do antihistamines cause increased AUC for Xanax, or how do they affect all the pharmacodynamics? That’s interesting.
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Do you know if it’s something in tobacco specifically or is it the nicotine that does it so vaping exc could/would cause the same reduced benzo levels effect as cig smoking?
 
Layne_Cobain said:
I remember hearing or reading something like that years ago that nicotine or tobacco (can’t remember which) can lessen the effects of benzos…never knew caffeine could also though…
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How long from last cup of coffee? 4 hours, 8 hours? I never drink it past 4 pm. TY
 
if i had access to whatever, this is what i would use if i wanted to increase alp. Mainly the rest of the gaba system. gabapenteniods, one drink, small dose barbs. baclofen is great, as poster above stated. the effects on gaba-b really make baclofen stand out to me. maybe tiny g at peak.

if i was hard up i'd do stuff like cimetidine. intimately familiar with my whole ordered list of potentiators every time back in the PST days.
 
Strongbull said:
I wanted to share this information with the other members of the board who use x@n@x as a medication.

If you are running low on your x@n@x or want to increase its effectiveness without increasing your dosage, taking these medications along with it will increase 2mg of x@n@x into an effective dose between 6mg to 8mg.

Baclofen 20mg - Baclofen is a non-controlled medicine that is similar in structure to GABA. Your doctor should have no problem prescribing it to you.

Cimetidine (Tagamet) 200mg - Cimetidine is an OTC medicine for heartburn. It is a CYP3A4 liver enzyme inhibitor. The CYP3A4 enzyme is responsible for the clearance of x@n@x. So cimetidine inhibits the breakdown and clearance of x@n@x, which allows for a higher potency and duration of action.

Chlorphenimarine 4mg. Chlorphenimarine is an OTC antihistamine and extends the duration of action of x@n@x by about 5 hours.

When these three medications are taken along with your x@n@x they will increase the effective dose by about 3 to 4 times, and are extremely effective.

I hope this helps.
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Any off chance Gabapentin / Neurontin would help do the trick? Or anything at all for that matter? My psychiatrist gives this med to me knowing that I’ve never had any effectiveness of the medication and most psych MD’s only use it when you cannot use a benzo due to addiction or allergy. Sorry that was a runoff
 
Prozac administered concurrently with it also increases the effects. Not saying people should take anti depressants if they don’t need them but if you’re already on one and have access to Prozac….
 
Kind of off subject....Anyone use Loraza*** in place of Alpraz for sleepiness? Looking for a change up. TY. Other ideas welcome.
 
Baretree said:
Kind of off subject....Anyone use Loraza*** in place of Alpraz for sleepiness? Looking for a change up. TY. Other ideas welcome.
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I tried Lora, I woke up the next day with blurred vision the whole day. It never happened to me with alpra. Maybe it's just me?
 
ELMNTS360 said:
Any off chance Gabapentin / Neurontin would help do the trick? Or anything at all for that matter? My psychiatrist gives this med to me knowing that I’ve never had any effectiveness of the medication and most psych MD’s only use it when you cannot use a benzo due to addiction or allergy. Sorry that was a runoff
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Yes that will potentiate like baclofen
 
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