How to Increase the Potency and Length of Duration of Alprazolam by 3 to 4x

[Strongbull]

Why do antihistamines cause increased AUC for Xanax, or how do they affect all the pharmacodynamics? That’s interesting.

First generation antihistamines reduce Histamine-GABA Cross Talk.

You won’t get the same beneficial response on benzo action from second generation antihistamines like citirizine.

 

[Just-IN-case]

Ah, that makes more sense, I’d heard acidification (juice) increases excretion of certain stimulants, weakening their potency.

It’s an enzyme in the skin that inhibits the cyps to potentiate said item, that’s why eating a grapefruit is going ti do nothing. Word of advice there are three major otc items that would inhibit the enzymes CYP3A4 and CYP2D6, the ones you would want to inhibit, these also increase one’ tolerance more than just taking more of said item. There are also inhibitors you may want to look at your medications to see if they are active for said item. Be safe, lesss is always more

 

[Strongbull]

CYP3A4 and CYP2D6, the ones you would want to inhibit

If you are looking to increase length of duration (AUC and Mconc) of your benzo, you want to inhibit CPY3A4, which breaks down the benzo.

If you are taking opeeates you want to inhibit CYP3A4 and promote CPY2D6.

CYP2D6 plays no role in clearing benzos, but if you are taking opeeates you do not want to inhibit CYP2D6.

 

[Layne_Cobain]

Smoking will reduce (presumably all) benzodiazepines, according to findings in K-P/n research that suggests 50% reduced blood levels in cigarette smokers. Never heard anything about the coffee. Just causes some ph changes or is it enzymatic as well? Why do antihistamines cause increased AUC for Xanax, or how do they affect all the pharmacodynamics? That’s interesting.

Do you know if it’s something in tobacco specifically or is it the nicotine that does it so vaping exc could/would cause the same reduced benzo levels effect as cig smoking?

 

[Baretree]

What is AUC mean in regards to antihistamines? Not getting the lingo here. TY

 

[Baretree]

I remember hearing or reading something like that years ago that nicotine or tobacco (can’t remember which) can lessen the effects of benzos…never knew caffeine could also though…

How long from last cup of coffee? 4 hours, 8 hours? I never drink it past 4 pm. TY

 

[Icecoldicicle]

@Just-IN-case I don't have the ability to respond to you on the post you made on my profile. How can we get a hold of each other?

 

[webothgetout]

if i had access to whatever, this is what i would use if i wanted to increase alp. Mainly the rest of the gaba system. gabapenteniods, one drink, small dose barbs. baclofen is great, as poster above stated. the effects on gaba-b really make baclofen stand out to me. maybe tiny g at peak.

if i was hard up i'd do stuff like cimetidine. intimately familiar with my whole ordered list of potentiators every time back in the PST days.