Best for weight loss?

Dextrobeats · Oct 30, 2025

Dnels2015 said:
I just can’t get behind the glp antagonists… I’ve heard it’s killer if you don’t keep your diet clean. From the studies I’ve seen it can result in a lot of muscle loss (biggest issue with losing weight too quickly). I did try (trying to stand by rules here) a di-nitro phenolic oxidative uncoupler once. It was more to experience the heat than for weight loss. I slept under an open window in 9 degree F weather so yeah… the heat thing is real. I don’t recommend it to anyone really.

Odd to say here, but body composition changes are better done without supplementation. Slow and steady wins this race.

Triple agonists don’t seem to demonstrate any muscle loss with proper diet and training. DNP is the only thing that will actually burn fat without all the fundamentals in place but you are gambling with your life. Couldn’t pay me to touch that stuff.

TronB · Oct 30, 2025

Dnels2015 said:
I just can’t get behind the glp antagonists… I’ve heard it’s killer if you don’t keep your diet clean. From the studies I’ve seen it can result in a lot of muscle loss (biggest issue with losing weight too quickly). I did try (trying to stand by rules here) a di-nitro phenolic oxidative uncoupler once. It was more to experience the heat than for weight loss. I slept under an open window in 9 degree F weather so yeah… the heat thing is real. I don’t recommend it to anyone really.

Odd to say here, but body composition changes are better done without supplementation. Slow and steady wins this race.

Retatrutide plus strength training and adequate protein results in no muscle loss. I lost 22 pounds in a month and lost no muscle, confirmed by dexa. I did lose strength until I went back to maintenence calories. 18% bodyfat to 10%, and Retatrutide made it easy. Science rules.

Deleted member 55144 · Oct 30, 2025

I think the mindless use of the GLP-1s leading to severe malnutrition is what gets people that coveted melted candle bod rather than it just being the nature of the ᎠᎡuᏩᎦ themselves. ᎦtᎥms can also be an effective weight loss tool, if you maintain sound nutrition and training, but can also completely supplant caloric requirements and lead to muscle, hair and tooth loss if used with reckless abandon.

Dnels2015 · Oct 31, 2025

Fair enough. I started on the skinny boi end of the spectrum. Finally got to 220 by supplementing 2 family sized jars of peanut butter a week. Most of the negatives I’ve heard are from folks that have not changed their diet and don’t exercise. I assume there is something downstream of ghrellin that makes you feel off on a bad diet.

Best for weight loss?

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