CL-218-872

bigjackchen

bigjackchen

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Jun 30, 2019
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NEW PRODUCT:

CL-218,872:
IUPAC NAME: 3-methyl-6-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[3,4-f]pyridazine
CAS Number: 66548-69-4
Chemical formula: C13H9F3N4
Molar mass: 278.238 g•mol−1



CL-218,872 is a sedative and hypnotic drug used in scientific research.It has similar effects to sedative-hypnotic benzodiazepine drugs such as triazolam, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic.

CL-218,872 is a GABAA partial agonist which is selective for the α1 subtype.[3][4][5] It has a range of effects including sedative, hypnotic, anxiolytic, anticonvulsant and amnestic actions, however the most prominent actions are sedation and amnesia, and CL-218,872 produces effects very similar to those of the hypnotic imidazopyridine derivative zolpidem in animal studies.
This product is intended for laboratory research purposes only and are not to be used for any other purposes.
 
It’s partial agonist across the 1-6 or just the 5 mainstream subunits? Also, partial at GABAAR1 subunit or it has more traditional affinity comparable to a-drugs? any antagonistic action that could boot out full agonist like diazepam but not be itself able to give effects at the subunit level, causing mucho distress if you’re a chronic full agonist user as if 2, 3 are outcompeting your Xanax but not producing the strong conformational and post synaptic molecular changes that bring that GABA in close for that anxiety relief - it’s gonna be just like a can of ambien-light that causes instant wash it and wd for that everyday user. Interesting and this is the way the research must go. Thanks!
 
It's like a zdrug hybrid personally I would stay away, Ive had my vendors offer it to me and I've said absolutely no thank you. I suggest you all do the same they label it as a benzo but it is not a benzo.
 
Eastnootropics said:
It's like a zdrug hybrid personally I would stay away, Ive had my vendors offer it to me and I've said absolutely no thank you. I suggest you all do the same they label it as a benzo but it is not a benzo.
Click to expand...
why do you recommend so strongly against this class? i'm not familiar with the reason z drugs are undesirable other than, i think, vague recall about intense nightmares and occasional sleep-walking and delirium associated with ambien.
 
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  16. st1ckyf1ng4z @ st1ckyf1ng4z: @MorfineOrfan like I said before I’m a recovering opiate addict so I choose not to touch the shit at all but I’ve been to smoke shops because I buy disposable vape products and other accessories, but every smoke shop I’ve been to over the last few years have had kratom “front and center” and easy to see. About 2/3 years ago 7oh products began appearing and it got completely out of control. I remember telling one of the owners of my regular shop that 7oh it’s not gonna end well
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  20. MorfineOrfan @ MorfineOrfan: @st1ckyf1ng4z i have no clue what the supply and demand is like for brick and mortar shops, i havnt been in a smokeshope in 15-20years and back then none of them had or even knew what kratom was. Ive always bought kratom from vendors online, back in tge day we would use babel fish translator to haggle with vendors on kilo prices lol. But you dont need to worry mit will always be available if leaf is.
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