CL-218-872

bigjackchen

Member
VENDOR ACCOUNT
Joined
Jun 30, 2019
Messages
523
NEW PRODUCT:

CL-218,872:
IUPAC NAME: 3-methyl-6-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[3,4-f]pyridazine
CAS Number: 66548-69-4
Chemical formula: C13H9F3N4
Molar mass: 278.238 g•mol−1



CL-218,872 is a sedative and hypnotic drug used in scientific research.It has similar effects to sedative-hypnotic benzodiazepine drugs such as triazolam, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic.

CL-218,872 is a GABAA partial agonist which is selective for the α1 subtype.[3][4][5] It has a range of effects including sedative, hypnotic, anxiolytic, anticonvulsant and amnestic actions, however the most prominent actions are sedation and amnesia, and CL-218,872 produces effects very similar to those of the hypnotic imidazopyridine derivative zolpidem in animal studies.
This product is intended for laboratory research purposes only and are not to be used for any other purposes.
 
It’s partial agonist across the 1-6 or just the 5 mainstream subunits? Also, partial at GABAAR1 subunit or it has more traditional affinity comparable to a-drugs? any antagonistic action that could boot out full agonist like diazepam but not be itself able to give effects at the subunit level, causing mucho distress if you’re a chronic full agonist user as if 2, 3 are outcompeting your Xanax but not producing the strong conformational and post synaptic molecular changes that bring that GABA in close for that anxiety relief - it’s gonna be just like a can of ambien-light that causes instant wash it and wd for that everyday user. Interesting and this is the way the research must go. Thanks!
 
It's like a zdrug hybrid personally I would stay away, Ive had my vendors offer it to me and I've said absolutely no thank you. I suggest you all do the same they label it as a benzo but it is not a benzo.
 
It's like a zdrug hybrid personally I would stay away, Ive had my vendors offer it to me and I've said absolutely no thank you. I suggest you all do the same they label it as a benzo but it is not a benzo.
why do you recommend so strongly against this class? i'm not familiar with the reason z drugs are undesirable other than, i think, vague recall about intense nightmares and occasional sleep-walking and delirium associated with ambien.
 
Drugbuyersguide Shoutbox
  1. tiquanunderwood @ tiquanunderwood: Happy Birthday @CalFresh
  2. Y @ Yaugae5121: Heyyoo happy birthday calfresh!!
  3. CalFresh @ CalFresh: To everyone awaiting responses from me: I am sorry I am behind. Today is my birthday and others are demanding my attention. I will mdo my best to catch up by EOD tomorrow. Apologies!
  4. xenxra @ xenxra: when the train leaves the station, it doesn't back up to let latecomers on. if it does, there's something wrong with the train.
  5. Gluonimatrix @ Gluonimatrix: 😽
  6. Professor_ @ Professor_: Good Morning everyone
  7. CalFresh @ CalFresh: happy Tuesday!
  8. T @ Thedoccc: Thank you all, as my wife says "God squeezes, but doesn't choke"
  9. N @ necromedic: @Thedoccc: Congratulations! The Father is merciful, and His blessings know no bounds.
  10. J @ jjjjjjjjj: @Thedoccc Congrats!! So happy for you!!
  11. WTF7218 @ WTF7218: Congratulations Thedoccc! That’s great news.
  12. L @ Layne_Cobain: Congrats bro!!! That’s awesome happy for yah you can let that stress go…stress is the enemy
  13. T @ Thedoccc: Hey y'all, wanted to tell you that I signed that second contract I was hoping for. Which should keep me afloat for the rest of the year, and hopefully 2026 if all goes well. Appreciate your encouragement, love, prayers and out reach. I was really feeling low last week and needed that extra bit of <3
  14. tiquanunderwood @ tiquanunderwood: hahhah right on man. they spent so much bread.
  15. L @ Layne_Cobain: Could b worse dude could be a met fan right now 😂 that payroll and no playoffs 😳 I kinda feel bad for em such an insane collapse and so insanely opposite of what happened last year with them starting terrible then catching fire all the way to the nlcs
  16. tiquanunderwood @ tiquanunderwood: That Texas playoff series last year crushed out spirits lmao. They wrecked us.
  17. tiquanunderwood @ tiquanunderwood: No you're pretty much spot on. We've been playing better since the firing of Hyde but I think it's just coincidence. Even though he was terrible at putting the correct relievers in at the wrong time.
  18. L @ Layne_Cobain: Exactly didn’t make a good enough offer to Burnes to keep him and didn’t go after any other top pitching then when things were over come deadline traded away a bunch altho I don’t think any of them besides O’hearn and maybe a reliever or two were doing that well but I could be remembering wrong
  19. tiquanunderwood @ tiquanunderwood: *bucks
  20. tiquanunderwood @ tiquanunderwood: Just needed pitching. And mister big buks didn't spend sh1it hahhaha.
Back
Top