melatonin enhances opiates and reverses tolerance?

@Gracie5  I totally agree about magnesium too.   I started taking it years ago for some irregular heartbeats, then continued taking it to counteract one of the.. unmentionable negative side effects of opiates,  and I've been touting its benefits for years.   It totally got rid of my skipped heartbeats and restless legs.  Every opiate user should add magnesium (I use citrate) to thier regimen.   I can't go without it!  (see what I did there)      :)

 
Nice pun, @Roxyanne! I originally started using because I was deficient. But I use for the same reason! Going a step further, I like to add a splash of pure aloe juice to my cuppa Calm- Calm already has the gaba, L Theanine, and melatonin, and Mag Citrate. I told my doctor about the aloe and he started recommending to his patients on Op8s. I know because he forgot I was the one who told him and recommended to me!

I’ve seen CBD Epsom salts online. It’s super pricey so I haven’t tried, but I know people who swear it helps with full body pain.

Apologies for being way off topic with my posts here, but all of these things have improved my sleep and digestive issues immensely. If they help with tolerance, even better!

 
Gracie5 said:
Something my doctor told me about Melatonin, which I have used for many years, is that you should take it about 30 minutes before you plan to fall asleep, and make sure you are resting and really ready to sleep for it to be effective. It’s also safe for children, according to my son’s doctor (son is 15, so not a young child).

Another natural sleep aid is L Tryptophan. Tryptophan is part of the reason you feel so tired after eating Thanksgiving dinner. 

I’ve always struggled with falling asleep, so I use these in combination with Magnesium. Magnesium is something in the body that can be depleted by stress, and it helps relax the body. It’s also in Epsom salts, so a nice bath with Epsom salts helps with relaxation and muscle aches.
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For magnesium “Natural Calm” was the only supplement that did anything. It’s a difficult mineral to assimilate and that makes it easier. I got awful insomnia too and that magnesium supplement worked the best. Bananas help too maybe because of the potassium they have. 

I use melatonin too but I cycle it. Taking too much will cause your own body to produce less. 

 
I can attest to this working. I take kratom daily, but no other opiates. My kratom tolerance kept going up until I started taking melatonin each night. NMDA receptor antagonists are shown to decrease opiate tolerance and melatonin apparently blocks NMDA in the spinal cord. It also helps me sleep if I dose my kratom too far before bed, then I don't sleep well unless I take melatonin.

I tried DXM also to reduce tolerance and I think it worked a little, but it gives me shits, so I can't really enjoy use it.

Maybe a low dose NMDA RC like 3-meo-xxx or whatever would help.

 
@Roxyanne my partner is a psych nurse working 12 hr shifts,  7a to 7p. By the time she gets home at about 8:30pm she’s so wired she has to talk (confidentiality  of course) for another hour to unwind. Her crazy job combined w/ years of insomnia makes it difficult for her to sleep; therefore it makes it hard for me to sleep. I bought 5mg gummy melatonin made by Spring Valley from Walmart. OMG not only do I fall asleep with that natural feeling but I remember dreaming. Apparently this means I am in REM state. That’s the deepest state where you’re rejuvenating your body and brain. She’s been taking hydroxozine with melatonin for years and has wanted me to take melatonin forever. I just didn’t think cherry 🍒 gummy bears would work....talk about SNORING! Holy molly😤. The windows rattle!!  Long story short...I sleep 💤 like a bambino.

Thanks!

 
@Roxyanne you're extremely SMART but melatonin speeds me Ritalin calms we are having a shortage down here if anyone can help I'll help ANYONE I can Ty so much

 
Melatonin is a hormone that sets your biological clock. It’s referred to as “ the vampire drug” because its mechanism works through the skin. No TV or lights on!!   It is effective in doses.3-5mg anything stronger does little to enhance sleep ( I don’t know, I take 10 mg) but amounts more than 5 mg can cause side effects especially with other medications, anticonvulsants, antidepressants, anticoagulants, blood pressure meds and immunosuppressant s. Yeah Yeah I hear the raspberries!!

There’s always one😂

Ref: The Sleep Doctor

 
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  4. Realbenzeyes @ Realbenzeyes: I always thought I should’ve been born in a much earlier time but I will say, i do enjoy my Xbox and occasional TV series tho 😂
  5. Realbenzeyes @ Realbenzeyes: I just wish the opioid epidemic never happened. Fk the turn of the century (which would be cool no doubt)! Many of my friends and family would’ve ended up in asylums like so many others. I just wish I could get back all those I’ve lost since the start
  6. L @ Layne_Cobain: 1914 I meant
  7. L @ Layne_Cobain: I often wish I lived during the turn of the century or at least before the Harrison narcotics act or whatever I think it was 1924 the fun ended but anyway yeh being able to get laudanum, ❄️ and amphetamine at the local friendly pharmacy
  8. Maelstrom @ Maelstrom: Chew on the leaves with a bit of slaked lime and enjoy the mild boost you get from the raw base.
  9. Maelstrom @ Maelstrom: I’m sure you know the folks in the mountainous regions along South Americas pacific side buy cócà leaves at the local farmers market just to help acclimate to the higher elevation when they have to head up into the hills.
  10. Maelstrom @ Maelstrom: I would certainly have bought it, swilled it, enjoyed it…. Why not? A little boost in your juice isn’t going to hurt anyone.
  11. R @ Royboy99: Exports were reported to have around 7.2mg per FL OZ, it’s success is what actually led to Coca Cola
  12. Maelstrom @ Maelstrom: Having cramps and husband thinks you’re acting hysterical (ie. PMS) the doc would either perform a certain massage to relieve the strains of motherhood and family life of that time or send you down to the local apothecary for a bottle of laudanum… A tincture of alcohol and 10% òpìųm. Fun days huh?
  13. R @ Royboy99: @malestrom: yeah thats it, my bad Mariani, yeah i considered that and also its ROA, which was oral so the bioavailability was lower than insufflation, higher degree of purity tho and longer duration … there was a significant marked increase of patents filed by Edison during the time it was released in the US. Presidents were known to use it as well, and the Queen. The pope awarded the wine the Vatican gold medal award
  14. Maelstrom @ Maelstrom: I think it was called vin Mariani. But yeah, it was all the rave back in the turn to the 20th century. Original formula Coca Cola did it for a while too. I think it was pretty weak though. Something like 200 mg per liter of wine. Enough to maybe give you a little push but unless you could pound some serious alcohol, it’d be hard to really feel the effects before the ethyl knocked you down on the ground. It was an interesting time period. Laudanum was a “hysterical” woman’s best friend.
  15. R @ Royboy99: Maybe it’s the admixture of my South American dna that works so well with it ? 🤷
  16. R @ Royboy99: It’s all evident in memory recall, my emails, meetings, … people invest everything they have in a nootropic that provides this… desperately searching without success and it’s right there right under their nose (no pun) … stigmatized by society and outlawed.
  17. R @ Royboy99: Now I’m not foolish or delusional to think that it made Edison who he was … it just allowed him to Edison to Edison to a greater degree … and I see it doing that for me and others who use it as a productive tool and not a substance of abuse.. you can look at this data with the level of patents filed by Edison during that time … comparable to Barry bonds or McGuire breaking records while they were subtly enhanced
  18. R @ Royboy99: One could argue that we would not have motion pictures if it wasn’t for ❄️
  19. R @ Royboy99: I also take month long breaks and replace with Ritalin for receptor recovery
  20. R @ Royboy99: And while it may sound insane and completely destructive … small microdoses of ❄️ has really transformed me. I did extensive research on its use by Edison, the pope at the time, and many others who got great benefit from a wine concoction called vin Mariani … this subtle enhancement changed the world and as long its used with a high degree of control, it’s amazing. you may think I’m crazy … but I’m just being as transparent as I can
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