Orange Juice And Grapefruit Juice Enhances Potency

[mellowout]

That is so interesting to know. I take Benzo's always read on the bottle to not mix with grapefruit or the juice just never thought to look up why... Thanks guys, that is good to know !

 

[cavzfan5012]

this really isn't true. It doesn't potentiate it but it slows down the metabolities that break it down so basically it just increases the duration of the effects

 

[kiki0730]

I was vey curious about this topic so I did some research and came up with a pretty good article on grapefruit juice and bensos.  Mods, please feel free to edit if I have broken any rules. I did my best to edit out many of the meds.  

There’s been quite a lot of conflicting information about whether or not various benzos are potentiated by grapefruit juice or not: So here for your viewing pleasure is what has been able to dig up.

Grapefruit juice inhibits Cytochrome P450 (CY3PA specifically), which is found both in the liver and the wall of the small intestine. These enzymes metabolise benzodiazepines. The theory is, is that if the enzymes are inhibited then there will be greater bioavailability of the drug (for example, requiring lower doses to get the same effect). However it’s not quite so simple. This effect only comes into play if the parent drug is subject to extensive first pass metabolism. Drugs with high oral bioavailability (because of low first pass metabolism) are not affected by enzyme inhibition significantly.

Obviously grapefruit juice does not have an effect if benzodiazepines are taken parenterally (IV or IM), because first pass metabolism is eliminated.

People have seen it stated in various places on the net that it is only ruby grapefruit that has effect: Not so. Most of the studies were done with normal white grapefruit.

So, here we go.

Benzos definitely potentiated by grapefruit juice:

H@lci@m, V@ls and V@rs@d

Bensos definitely NOT potentiated by grapefruit juice:

Z@n@ies

Benzos theoretically potentiated by grapefruit juice, but effects probably not clinically significant (because of high oral bioavailability):

Kl@nop@n, Add@v@n, D@lm@ne, R@st@ril

NB: No studies have been done on these benzos specifically

Another factor that comes into play is the duration of intake of grapefruit juice. Tri@zol*m particularly has been studied. Studies have shown that although a single glass of juice increases plasma concentrations and half-life, repeated glasses of juice over three days has an even greater effect. This effect lasts for about 3 days after discontinuation of grapefruit juice.

Some other tit bits gleaned: Grapefruit juice is not the only juice to inhibit CY3PA. Others having an effect are: black mulberry > wild grape > pomegranate > black raspberry. All however have less of an effect than grapefruit. Star Fruit also appears to be a potent enzyme inhibitor. Pomegranate juice also inhibits CY3PA

On a side note: Other downers affected by grapefruit juice are: bus@ir@n% (strongly clinically significant), Z@lepi@ne (moderate significance), and Z@lpi@m(unlikely to be clinically significant).
 

 

[idan1120]

In fact, through my *personal studies*, I've come to learn that the best way to increase the meds effect is to pair your benz' with a few ice cold bottles of budweiser.

Call me old fashioned, thats what works best for me /default_wink.png

My sentiments exactly. Orange or grapefruit juice never made a noticeable difference for me. Budweiser always made a tremendous one. Lol

 

[ben zoe]

There are lots of potentiaters just be carefull.gaba(gamma aminobuteric acid) is a grate potentiater over the counter.clonodine.quinine also. But never heard of o.j. potentiating opiates. I know it contains vitamin c which inhibits the absorption of opiates

 

[blissopifree 2]

I remember a friend who had a (bad trip)on acid over 20 years ago,we gave him lots of fresh orange juice and it seemed to help him come outa the (bad trip).

Nor really relating to the thread but all the talk of fruit juice triggered something in my head ?.

Bliss....

 

[LoopHole]

Just grapefruit juice.  White grapefruit juice is the better of the varieties out there. Orange juice doesn't do shit to inhibit the receptors that are inhibited by grapefruit. Tagamet works on the same pathways.

 

[blissopifree 2]

Pure grapefruit juice  (not pink) does potentiate di@zap@m in my experience but perhaps it just prolongs the effectiveness of the di@z.But this doesn't work with x@n@x so not all BNZs just probably the ones highlighted in the above post.

Most informative btw.....

Bliss....

 

[chitownlp]

Orange juice doesn't potentate.  Pure grapefruit juice will potentate most thinks according to articles I've read.

 

[Biteme]

It can mess up a lot of other medications too:

https://www.poz.com/article/Grapefruit-Medications-23319-9413

 

[VII]

Wow, this is actually the first time that I've heard something like this believe it or not and I've had scripts for over a decade for these types of meds. My question is (may of already been answered, haven't fully read through the thread yet) seeing I have a high tolerance to these meds and supposedly these juices increase the potency does it actually effect the tolerance at all? I mean yes, if it effects the potency of the meds then clearly it will develop a higher tolerance to it but in the case of being exposed to these medications for a very prolonged period of time would raise the tolerance levels.

If so, I need to stay away from it. Hints why I'm asking, I need to be tapered off them eventually and increasing the potency is not my goal. 

 

[Deeps_MindQuest]

i used to hear about grapefruit juice and tried it several times i never noticed any enhanced effects not even once.