I am not a doctor, chemist or pharmaceutical employee so the following is just my opinion:
IMHO ALKS5461 could revolutionize the recovery industry. It combines bupe and an additional molecule that prevents bupe from binding to the brain's receptors. this could deal with the biggest drawback of bupe treatment - how to get off the stuff.
Keep in mind that bupe only blocks other opiates and sends a mild signal of its own to minimize cravings and eliminate withdrawal putting the patient in remission. This new drug has properties of its own that are expected to deal with certain forms of depression, anxiety/panic and chronic-pain. In combination with the appropriate therapy (PT, psych, etc) patients could become drug-free.
The biggest glitch with bupe is how to get off the stuff. There are volumes written on how to induce, start, initiate bupe treatment, but not one official authoritative protocol (that I can find) for getting off the stuff. ALKS5461 prevents bupe from binding to the mu receptors in the first place making the mild euphoria and later psychological dependence unlikely. Of course none of this will work without ultimately treating the underlying root causes of the problem (GAD, MDD, spinal injuries, etc.), but this med is supposedly a treatment that won't cause its own dependence and have true antidepressant properties.
This is all kinda speculative at this point because the drug is still in clinical trials, but they look promising.
I personally am not a fan of Vivitrol because of those I know who reacted badly to it, but this is just MHO. Vivitrol is simply a long-acting (monthly) injectible form of Naltrexone, a full opiate ANtagonist which physically prevents patients from relapsing. Naltrexone is one of the options used when a patient is brought to the ER overdosing on opiates.
Very interesting developments, however!