Wellbutrin

Angelical

Member
Joined
Oct 11, 2024
Messages
5
I want Everyone to take a look at Anti-Depressants. We have all heard of SSRIs causing Women to say God told them to drown their Children, or put their Baby in the Oven, when they stopped taking their SSRI, and I want everyone to understand how some of these Work, and get into the Biochemistry. First, the Theory being used with these Drugs is the “Brain Chemistry Theory”, where we assume that Mental Health issues come from an imbalance of Brain Chemistry. The Theory so being that if Serotonin is Low then a Selective Serotonin Reuptake Inhibitor (SSRI) will Raise the Levels of Natural Serotonin, thereby balancing out an otherwise Low Serotonin imbalance. It’s the same Theory as Schizophrenia Medication which does the Opposite and Lowers Dopamine and Serotonin Levels, as Hallucinations come from Activity in those Parts of the Brain. There used to be Anti-Depressants that worked as MAOIs, a lot of Medication was like Seroquel and Xanax or Valium do Today, and they would kind of numb the Emotions, kind of Sedate a person, like Thorazine, the main class was Barbituates and now Benzos are the most Common. Anti-Depressants were MAOIs though. MAOIs work on kind of the Ayahuasca Theory and we can compare all of these SSRIs and Ayahuasca, etc to Peyote also. Ayahuasca contains MAOIs and DMT, Peyote contains just Mescaline. The Brain Balance Theory then usually is being used with Reuptake Inhibitors, not Agonists like Peyote (which not just inhibits Reuptake, but Acts on the Receptors itself). And knowing that these Medicines are working this way, we can add to them, for example Melatonin can be taken at Night, as well as 5-HTP, or L-Dopa, etc, and all of this would expand on the Brain Chemistry Theory.

Anti-Depressants
So let’s get into how the work and make another comparison there are SSRIs, SNRIs and SDNRIs and Amphetamine and Phenidate, I mention those 2, which are Adderal and Ritilin, to make the Point that these Anti-Depressants, particularly the SDNRIs, are “Triple Reuptake Inhibitors”, so they are comparable to Amphetamine, Methyl-Amphetamine (Methamphetamine) and Phenidate and Methylphenidate, but those themselves are Prescription Medications and so are themselves actually Different. Wellbutrin for example, to make the Point, is a Triple Reuptake Inhibitor, does help Suppress Appetite, and also helps with Depression, may be Habit Forming, and could lead to Withdrawals if You stop taking it, but it is not Meth, or Cocaine, it is its own Thing. Then there are the SSRIs which are much weaker, and less Stimulating, as the N in SDNRI and SNRI is “Norepinephrine” and Epinephrine is Adrenaline, like an Epi Pen, so the Norepinephrine Reuptake means Your Adrenal System uses all of its Materials. Comparing Wellbutrin to ADHD Medication, Wellbutrin is more like Strattera than Adderal. Strattera is a Non-Stimulant ADHD Med that works much like Anti-Depressants but was never approved for Treating Depression.

So these should be used by People that need these Things. People with Deficiencies, as like Restless Leg Syndrome where You actually need Dopamine to sleep because of an imbalance, there are People that need this. And I share this so they can find what they need.

And lastly, Mucuna Puriens, Velvet Bean Seeds contain all that You would need to help increase effectiveness of the Medication. Then there is also Chacruna, which contains DMT but is not active without an MAOI, so in a Tea form for example alongside just Mucuna and say Wellbutrin, it would just add to the Serotonin System. There is also Ephedrine, which is a Asthma Medication, but if You mix it with Wellbutrin You could have a Seizure. Ephedrine should be used by itself, or in extremely low Doses. What it does is the same as Methamphetamine or Amphetamine also, except is also does the Releasing Part. Anti-Depressants just let You use all of Your own Supply, Ephedrine Adds to the Supply of Dopamine and Norepinephrine, so it Adds that extra Part. This could cause a Seizure though, so People taking Wellbutrin, Strattera, etc, should be very Careful with Ephedrine because their Brain Chemistry is Changed by the Wellbutrin and the Strattera, and it could be like 5x to 10x as Strong for You, than it would be for someone who was not taking Reuptake inhibitors.

I want Everyone to know about this, because there is:

1. A fear based on Stories of New Mothers killing Babies, that is maybe not such a well founded fear
2. Abuse, so People should know what it’s for and then also know that abuse, like Snorting can cause Seizures, and in many cases is more Painful than other substances.

And lastly, Medications like Remeron and Doxepine could also be added for Night to help with Sleep, unless You like Seroquel which also adds Dopamine. Seroquel in my opinion is just too Drowsy all Day all the Time. But I Hope this Helps some People, and Helps People Help People, as maybe You could suggest something to Help someone You know.
 
I want to get more Granular with all of this so that Everyone can have as much information as Possible.

First,
Wellbutrin is a Cathinone, it is the only Cathinone that is a Legal Prescription in the United States, meaning that it is an example of what Research Chemicals can be if they are actually Clinically Studied through the Investigational New Drug (IND) Program. In other Words, You can go to Your Doctor and tell them about a Research Chemical and ask them to Prescribe it to You, but You have to have a Really Good reason. Under Donald Trump this was opened up in America under the "Right to Try" Rule, which was Basically saying "A Person who is Dying of Cancer, or another Fatal Illness, may try whatever the want". And being a Cathinone, that means Wellbutrin is related to the Substances in the Khat Plant, as well as Mephedrone (Meow Meow), etc.

I would actually compare it also to Things like bk-MDMA, meaning that it acts Different for Different People and can cause Seizures and Everything. MDMA is Ecstasy, and Ecstasy has pretty normal Dosages person to person, with similar effects in each Person, but substances like bk-MDMA are much more varied. Different Dosages, and even the same Dosage, cause a Range of effects for Different People. We could say that Wellbutrin is kind of Closer to these Molecules because of the Structure.

This shows the Family of Molecules, with the Cathinones on the Right and the Amphetamines on the left. They are all Very Similar.

3-s2.0-B9780128054550000038-f03-01-9780128054550.jpg



This is Wellbutrin, and we could say that the Reason people are having Seizures is because of that weird Structure hanging off the bottom Right hand side, all that extra is what makes it a little more Dangerous than Cathinone or Amphetamine. But this is also why they Prescribe it. This Dangling Structure on the Right make it:
1. Hard to Synthesize, so it could be Patented in the first place
2. Seems to have taken away the Dopamine and Serotonin and Norepinephrine and Oxytocin releasing Effect of the rest of the Family of Molecules, making Bupropion (Wellbutrin) more of a Reuptake inhibitor instead of a Drug of Abuse
bupropion_2d.gif

Some People say that the way Bupropion (Wellbutrin) Works is not by making You Happy Necessarily, regarding the Anti-Depressant Prescription, but instead makes Other Activities more Enjoyable. It Blocks the Reuptake of Dopamine, so instead of Adding Dopamine it lets YOU Add the Dopamine with Activities, and the Activities become more Enjoyable as the Dopamine is Blocked from being Reuptaken. A way to better understand this is by comparing the Actions of Reuptake inhibitors to Esterase inhibitors. Esterase is something in Your Body that Eats something, for example Acetylcholine Esterase is in Your Body breaking apart Acetylcholine, Acetylcholine Esterase goes around Your Brain looking for Acetylcholine, and anything that it finds it breaks it down into Other Molecules. If You take an Acetylcholine Esterase inhibitor it will stop the Esterase and Your Body will have more Acetylcholine. Reuptake inhibitors work much the same way, except they Block the Reuptake. Blocking the Reuptake of Dopamine means that any Dopamine in Your Brain has to be used and does not get "Reuptaken" into the Bloodstream and Urinary Tract. It gets used in the Brain. So the Anti-Depressant Effect comes from that.

CYP2B6 is the primary enzyme that metabolizes bupropion into hydroxybupropion. Bupropion is therefore a potent inhibitor of CYP2D6 activity. Atomoxetine (Strattera) is metabolized primarily through the CYP2D6 enzymatic pathway. This is why Mixing the Molecules becomes more Dangerous. CYP2D6 is known to Break Down about 25% of Drugs on the Market. https://www.sciencedirect.com/science/article/pii/S1110863017300228

So what Happens when You start Mixing Things like Wellbutrin and Strattera is they make each Other 5x to 10x Stronger, because Your Enzymes are inhibited, and therefor they do not Breakdown what is in the Blood Stream and the Brain. And so, if You took a Time Release Capsule of Wellbutrin, then decided to Snort of Strattera for example, You might be ok, but You increase Your Blood Levels, the same as Blood Alcohol content, and because the Enzymes don't Break it Down, it stays in Your Bloodstream. So then if You take more Strattera, the First dose hasn't left Your Bloodstream yet, and You might end up Overdosing much easier. This is the Danger with Wellbutrin, it is all about the Blood Levels. This is how People have Seizures from Overdosing on Wellbutrin, their Blood Concentration gets too high. It's not about how much they took over the Day necessarily, it is about how much they have in their Blood at any given moment. It also then causes Other Substances to build up in the Blood, by inhibiting the CYP2D6 Enzyme.

I just wanted to add all of this for Harm Reduction Purposes.

But because of the Dangers, and the Success of Wellbutrin as an Anti-Depressant, and Smoking Cessation Aid, and Diet Pill, etc, there may be Merit in looking at Research Chemicals in this Family for Clinical Studies, and I wrote this so maybe even some Clinicians and Doctors and Scientists can Recognize the Family of Molecules here, and maybe Create the next Substance that is better than Wellbutrin (maybe less Dangerous).

I know what I know, because I have been Studying Sasha Shulgin's Research since I was a Child. I always thought he was kind of like the Reason People even took Research Chemicals, as a kid I thought it was all working kind of how Sasha Shulgin would want, but I found that Researchers didn't even know who he was. Then Fentanyl and Br-Fentanyl, etc, Flooded the Research Chemical Market and I watched the entire Field be Destroyed. Where People were taking 5-MeO-DMT and 2C-I, they switched to Fentanyl, because it was still available when the Others were made Illegal. But I want everyone to understand these Things the way Sasha Shulgin understood these Things. He Writes specifically about this Family of Molecules (Phenethylamines), in his Book PIHKAL, and I suggest Everyone Order a Copy of the Book.
 
I want to get more Granular with all of this so that Everyone can have as much information as Possible.

First,
Wellbutrin is a Cathinone, it is the only Cathinone that is a Legal Prescription in the United States, meaning that it is an example of what Research Chemicals can be if they are actually Clinically Studied through the Investigational New Drug (IND) Program. In other Words, You can go to Your Doctor and tell them about a Research Chemical and ask them to Prescribe it to You, but You have to have a Really Good reason. Under Donald Trump this was opened up in America under the "Right to Try" Rule, which was Basically saying "A Person who is Dying of Cancer, or another Fatal Illness, may try whatever the want". And being a Cathinone, that means Wellbutrin is related to the Substances in the Khat Plant, as well as Mephedrone (Meow Meow), etc.

I would actually compare it also to Things like bk-MDMA, meaning that it acts Different for Different People and can cause Seizures and Everything. MDMA is Ecstasy, and Ecstasy has pretty normal Dosages person to person, with similar effects in each Person, but substances like bk-MDMA are much more varied. Different Dosages, and even the same Dosage, cause a Range of effects for Different People. We could say that Wellbutrin is kind of Closer to these Molecules because of the Structure.

This shows the Family of Molecules, with the Cathinones on the Right and the Amphetamines on the left. They are all Very Similar.

View attachment 4925



This is Wellbutrin, and we could say that the Reason people are having Seizures is because of that weird Structure hanging off the bottom Right hand side, all that extra is what makes it a little more Dangerous than Cathinone or Amphetamine. But this is also why they Prescribe it. This Dangling Structure on the Right make it:
1. Hard to Synthesize, so it could be Patented in the first place
2. Seems to have taken away the Dopamine and Serotonin and Norepinephrine and Oxytocin releasing Effect of the rest of the Family of Molecules, making Bupropion (Wellbutrin) more of a Reuptake inhibitor instead of a Drug of Abuse
View attachment 4926

Some People say that the way Bupropion (Wellbutrin) Works is not by making You Happy Necessarily, regarding the Anti-Depressant Prescription, but instead makes Other Activities more Enjoyable. It Blocks the Reuptake of Dopamine, so instead of Adding Dopamine it lets YOU Add the Dopamine with Activities, and the Activities become more Enjoyable as the Dopamine is Blocked from being Reuptaken. A way to better understand this is by comparing the Actions of Reuptake inhibitors to Esterase inhibitors. Esterase is something in Your Body that Eats something, for example Acetylcholine Esterase is in Your Body breaking apart Acetylcholine, Acetylcholine Esterase goes around Your Brain looking for Acetylcholine, and anything that it finds it breaks it down into Other Molecules. If You take an Acetylcholine Esterase inhibitor it will stop the Esterase and Your Body will have more Acetylcholine. Reuptake inhibitors work much the same way, except they Block the Reuptake. Blocking the Reuptake of Dopamine means that any Dopamine in Your Brain has to be used and does not get "Reuptaken" into the Bloodstream and Urinary Tract. It gets used in the Brain. So the Anti-Depressant Effect comes from that.

CYP2B6 is the primary enzyme that metabolizes bupropion into hydroxybupropion. Bupropion is therefore a potent inhibitor of CYP2D6 activity. Atomoxetine (Strattera) is metabolized primarily through the CYP2D6 enzymatic pathway. This is why Mixing the Molecules becomes more Dangerous. CYP2D6 is known to Break Down about 25% of Drugs on the Market. https://www.sciencedirect.com/science/article/pii/S1110863017300228

So what Happens when You start Mixing Things like Wellbutrin and Strattera is they make each Other 5x to 10x Stronger, because Your Enzymes are inhibited, and therefor they do not Breakdown what is in the Blood Stream and the Brain. And so, if You took a Time Release Capsule of Wellbutrin, then decided to Snort of Strattera for example, You might be ok, but You increase Your Blood Levels, the same as Blood Alcohol content, and because the Enzymes don't Break it Down, it stays in Your Bloodstream. So then if You take more Strattera, the First dose hasn't left Your Bloodstream yet, and You might end up Overdosing much easier. This is the Danger with Wellbutrin, it is all about the Blood Levels. This is how People have Seizures from Overdosing on Wellbutrin, their Blood Concentration gets too high. It's not about how much they took over the Day necessarily, it is about how much they have in their Blood at any given moment. It also then causes Other Substances to build up in the Blood, by inhibiting the CYP2D6 Enzyme.

I just wanted to add all of this for Harm Reduction Purposes.

But because of the Dangers, and the Success of Wellbutrin as an Anti-Depressant, and Smoking Cessation Aid, and Diet Pill, etc, there may be Merit in looking at Research Chemicals in this Family for Clinical Studies, and I wrote this so maybe even some Clinicians and Doctors and Scientists can Recognize the Family of Molecules here, and maybe Create the next Substance that is better than Wellbutrin (maybe less Dangerous).

I know what I know, because I have been Studying Sasha Shulgin's Research since I was a Child. I always thought he was kind of like the Reason People even took Research Chemicals, as a kid I thought it was all working kind of how Sasha Shulgin would want, but I found that Researchers didn't even know who he was. Then Fentanyl and Br-Fentanyl, etc, Flooded the Research Chemical Market and I watched the entire Field be Destroyed. Where People were taking 5-MeO-DMT and 2C-I, they switched to Fentanyl, because it was still available when the Others were made Illegal. But I want everyone to understand these Things the way Sasha Shulgin understood these Things. He Writes specifically about this Family of Molecules (Phenethylamines), in his Book PIHKAL, and I suggest Everyone Order a Copy of the Book.
Very informative. I had no idea Welbutrin was a cathinone. You said they use it as a diet drug too? I thought that was one of the anti-depressants that made everyone who took it fat and gain a lot of weight.
 
Very informative. I had no idea Welbutrin was a cathinone. You said they use it as a diet drug too? I thought that was one of the anti-depressants that made everyone who took it fat and gain a lot of weight.
Nope. Zoloft made me do that. I took both Zoloft and Wellbutrin. I stopped taking the Zoloft, and now I have like zero appetite, which isn’t good either. (I also just got over opioid withdrawal too. It sucked but I’m starting to feel more normal again.) Wellbutrin is something a lot of people that are afraid of gaining weight from an antidepressant take so they don’t. I don’t find it nearly as good as the Zoloft for depression, though.
 
Nope. Zoloft made me do that. I took both Zoloft and Wellbutrin. I stopped taking the Zoloft, and now I have like zero appetite, which isn’t good either. (I also just got over opioid withdrawal too. It sucked but I’m starting to feel more normal again.) Wellbutrin is something a lot of people that are afraid of gaining weight from an antidepressant take so they don’t. I don’t find it nearly as good as the Zoloft for depression, though.
Good for you on kicking the opis. I’ve kicked over 14 times for more than a month, but this last time with the Fent I couldn’t just switch to subs like usual and do a 2 or 4 week taper. I tried so many times but subs just couldn’t cut it. I ended up getting on methadone and that’s making me gain weight like crazy and I’ve never had any trouble whatsoever not gaining weight.

Doctors have been trying to get me to take antidepressants since I was a teenager but I’ve been an addict for so long and I figured the last thing I need is another drug to be dependent on. Lately though I’ve been thinking about trying them. I have no ambition or motivation.
 
Did you guys know that Wellbutrin, in addition to being formulated by itself, is also part of a new antidepressant that is a mix of it and FUCKING DXM. Yes, the one teenagers robotrip on.

This is it: https://en.m.wikipedia.org/wiki/Dextromethorphan/bupropion

Turns out DXM is an SSRI and SNRI, oddly enough, but it gets metabolized too quickly to be of much use (it gets converted into the NMDA antagonist dextrorphan that fucks you up).

That's why they combined it with buproprion. Buproprion - as mentioned in this thread - is a strong CYP2D6 inhibitor, and it drastically slows DXM metabolism, keeping it around long enough to have a clinical effect.

I assume the price will be *thousands* of dollars, though I really, really, really hope doctors just prescribe generic bupropion for a few bucks and tell patients to hit up CVS for the DXM. Congrats, now you'd be a generic pharmaceutical company 😄
 
Very informative. I had no idea Welbutrin was a cathinone. You said they use it as a diet drug too? I thought that was one of the anti-depressants that made everyone who took it fat and gain a lot of weight.
Yeah it’s a Cathinone, and the Weight Loss Formulation is called “Contrave”. It’s meant to hit the Reward Centers in the Brain and replace Binge Eating as a Reward System.
 
So I have my own Wellbutrin XR story. It’s the only anti-depressant that helps my anxiety. I can’t honestly say if it helps with weight loss. I have lost about 40 lbs since I started using it over 5 years ago, but I can’t say they are related. It definitely does not cause weight gain, as other drugs used for this purpose.
It can be compounded with extra low dose Naltoxene to make a weight loss/anti anxiety/fibromyalgia drug. Insurance typically won’t cover that.
My DD told me that my brain likes Dopamine, which is why it works for me. The other anti depressants contain Serotonin, which my brain does not like. (Some of you may know which types of us here may respond better to dopamine!)
There’s a blood test to determine if you process drugs properly. When I took it, it broke down about ten particular diseases and the drugs that work best for your liver. You can have genetic abnormalities that affect this.
So Wellbutrin works for me very well. I do not process drugs correctly and have a heterozygous disorder, so Wellbutrin not being processed too quickly helps (thanks @Angelical for sharing your research)!
 
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So I have my own Wellbutrin XR story. It’s the only anti-depressant that helps my anxiety. I can’t honestly say if it helps with weight loss. I have lost about 40 lbs since I started using it over 5 years ago, but I can’t say they are related. It definitely does not cause weight gain, as other drugs used for this purpose.
It can be compounded with extra low dose Naltoxene to make a weight loss/anti anxiety/fibromyalgia drug. Insurance typically won’t cover that.
My DD told me that my brain likes Dopamine, which is why it works for me. The other anti depressants contain Serotonin, which my brain does not like.
@Angelical for sharing your research!

Thank you for sharing such a positive experience! My psychiatrist thinks Wellbutrin is the perfect med for me - I have learned helplessness fatigue and depression, GAD, lots of other stuff, and Wellbutrin is eerie in how specific it is at treating those.

But... it's associated more strongly than any other antidepressant with hair loss, and I already have steadily increasing loss at the crown, plus thinning elsewhere, even without Wellbutrin. I just got divorced and my ego/confidence would be annihilated were my hair loss to accelerate.

So for now I won't take it. I need to get on the hair growth treatments and then Wellbutrin, and maybe a new, better me awaits 😄
 
Thank you for sharing @DrinkingDrano. I didn’t know about hair loss! It has not affected me that way. I tried it because it worked so well for my dad, who originally used it to stop smoking. He didn’t experience hair loss either, but he had very thick hair. Yes, it also helped with energy too
Best of luck to you in your work toward a better you! :)
 
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  1. uncharted @ uncharted: @xenxra It's not the best advice but you could alway's bind a RAT to PDF file and pose as a lawyer from a different email saying someting about sueing or anything you can think that would make them scared/curious/greedy enough to open it and then drain their crypto or find out who it is and pinpoint their location and file charges. Just brainstorming.
  2. xenxra @ xenxra: I've opened a case with numerous exchanges at this point to monitor all the addresses I have on hand but after a lot of bakc and forth they all ultimately suggest I file a report with local PD but the people in my area are generally definitely not savvy enough to handle a case like this so I'd be left waiting around for them.to pass my case upto secret service or something
  3. xenxra @ xenxra: not a bad idea, I'm open to anything. problem is I don't really have a direct method of contact with the attacker. they used a VPN with a Google voice number to reach me.bc my number was leaked in a data breach (like 10 times at this point) and then the rest of the ordeal was carried out through a falsified coinbase front-end. atm I'm mostly just concerned with getting any phone numbers I have on hand suspended (done) and as many addresses as possible frozen (in progress)
  4. uncharted @ uncharted: @xenxra It's not the best advice but you could alway's bind a RAT to PDF file and send them an email from a differnt email posing as a lawyer/or some authority figure from a saying someting about sueing/fake affidavit or anything you can think that would make them scared/curious/greedy enough to open it and then drain their crypto or find out who it is and pinpoint their location and file charges. Just brainstorming.
  5. xenxra @ xenxra: appreciate the kind words everyone. I think I'll make it. if I can even just so much as manage to get one of these guys locked up with the trail.i have on them then I can sit well with that. based on a couple addresses I've come across they've taken at least $5mil total from other victims.
  6. T @ timyboy: BTC is soaring woohoo
  7. K @ knofflebon: @xenxra fuuuuuuuck I'm so sorry to hear that, goddamn. Crypto scammers are getting so sophisticated these days. Here's hoping this won't keep you down for too long, painful though it may be.
  8. PHXINC @ PHXINC: i dunno its not up my field. I understand you being over it. im sorry and people suck. shit i was pissed when the snow kids took 1200 from me. You have a good balance. kudos to you. There is another 100k out there.
  9. PHXINC @ PHXINC: i dunno its not up my field. I understand you being over it. im sorry and people suck. shit i was pissed when the snow kids took 1200 from me. Right before that i had a very large amount of things taken from me from a 'friend' through a combined deal to his drop of course. You have a good balance. kudos to you. There is another 100k out there.
  10. RiftChems @ RiftChems: My american heart shines bright tonight
  11. R @ rasetreydir: xenxra wow, 100k? So sorry to hear this but i I admire your patience, and optimism. I cant even pretend I would know what to do if i was in your shoes. Good luck
  12. xenxra @ xenxra: i mean i know how to do bc analytics and such so i figure the only thing a "hacker" on dread would be able to do is counter manipulate the dude but i have no method to contact him anyway besides maybe leaving a spooky note on chain with one of the eth addresses they funneled through
  13. xenxra @ xenxra: im honestly over it already, you live and learn.
  14. xenxra @ xenxra: meh not worth it. i know how to trade so i can bounce back in the end if im not able to recover it. i already spoke to binance and had three accounts frozen and im filing a police report tomorrow.
  15. PHXINC @ PHXINC: Go to the hacker forum on dread, i will say no more. People salivate for jobs like this. they gonna want 25-50% of your coin though if they get it.
  16. xenxra @ xenxra: looks like i lucked out and i might be able to trace this scumlord down
  17. xenxra @ xenxra: @PHXINC it was a pretty complex script they hit me with. I would not be surprised to find out they know how to wash it but I am planning to start tracking it myself tonight. I filed a report with ic3 but I'm not sure how long it'd even take them to look into it.
  18. PHXINC @ PHXINC: Wow. Bitcoin that is easily traceable. Depends how good they are at cleansing it but many are not as good as they think. Go hire up. Shoud not cost too much.
  19. xenxra @ xenxra: it took me like 5 years to save up that bitcoin too
  20. xenxra @ xenxra: @BraveLittleToaster it was yesterday, i'm trying to stay optimistic but that was a pretty big chunk of my savings. no recourse to get any of it back due to where it was taken from.
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