You all should really try Bretazenil

[RClikeITS1999]

It's been a great anti anxiety for me. Great sleep.

 

[webothgetout]

i got some and from my research couldn't tell what it was. zero normal effects from others in same class.

when testing 20x normal dose as last chance to get relevant data the effects were almost like a disso where everything reverberated.

was really interested in bretazenil's potential as something to wean one off this class

 

[TheDude1234]

It's been a great anti anxiety for me. Great sleep.

I'm going to venture a guess that you aren't physically dependent on benzodiazepines. I am, and even though I knew it was a partial agonist, there were contradictory studies on whether or not it precipitated withdrawal in dependent individuals, so I decided to give it a shot.

Thank God it had a short half-life (literature says 1.5 hours), because for about 5 hours after taking it, I felt like I was on day 3 CT. And it has a crazy high binding affinity like naloxone, meaning the only way to get out of WDs is to wait it out or take an insanely high dose of a full BZD, which can easily be lethal.

 

[webothgetout]

I'm going to venture a guess that you aren't physically dependent on benzodiazepines. I am, and even though I knew it was a partial agonist, there were contradictory studies on whether or not it precipitated withdrawal in dependent individuals, so I decided to give it a shot.

Thank God it had a short half-life (literature says 1.5 hours), because for about 5 hours after taking it, I felt like I was on day 3 CT. And it has a crazy high binding affinity like naloxone, meaning the only way to get out of WDs is to wait it out or take an insanely high dose of a full BZD, which can easily be lethal.

very curious if this played a part in my very very weird experiences with it. did not all ALL feel like PW, though.

 

[luckyrabbit]

That's interesting. From what I've seen in my own studies of the literature is that it doesn't necessarily cause precipitated withdrawal in all dependent people. I'm super curious why it would in some cases but not all

 

[Hushhushmans]

I wish I could feel brave enough & have the free time to give it a go. It sounds promising in ways, but the risks seem to outweigh the benefits to me rn. It would be great if it worked well as a taper, but most things I’ve read make it seem like it with just give me PWD.

 

[webothgetout]

depending on which receptor sites the mags one subscribes to and the level of subscription might determine if pw happens? studies i've read use it compared it to standard mags while less widely spread ones that target diff audiences could have different effects?

i'm still really really curious wtf mag i might even have. ideas for best place to send copypasta to for editor analysis?

 

[RClikeITS1999]

Per Wikipedia: Bretazenil has a more broad spectrum of action than traditional benzodiazepines as it has been shown to have low affinity binding to α4 and α6 GABAA receptors in addition to acting on α1, α2, α3 and α5 subunits which traditional benzodiazepine drugs work on. The partial agonist imidazenil does not, however, act at these subunits.

On sleep:

Bretazenil alters the sleep EEG profile and causes a reduction in cortisol secretion and increases significantly the release of prolactin.[24] Bretazenil has effective hypnotic properties but impairs cognitive ability in humans. Bretazenil causes a reduction in the number of movements between sleep stages and delays movement into REM sleep. At a dosage of 0.5 mg of bretazenil REM sleep is decreased and stage 2 sleep is lengthened.[25]

 

[RClikeITS1999]

I am actually wondering if some place like clearnet leb site Ambeed.com would distribute this as it is totally uncontrolled.

They offer

$29.00/5g and https://www.ambeed.com/bretazenil.html​

which would be .0058 per dose.

Ambeed.com let me set up an account but I do not know if they wil sell to individuals without an LLC or a Corp. Ill email them now and get back to you.

 

[TheDude1234]

I have an update to my original post regarding PWD. I'm on like day 10 of CT due to supply issues. Been feeling all the expected symptoms.

Then I remembered I had a sample of it sitting in the drawer. I did volumetric this time, took a much more reasonable dose of roughly 1 mg and 30 minutes later I felt a significant reduction in anxiety, which has been so crippling I've barely left my house. Another 1 mg later, and my appetite has returned. I actually feel like I want to eat and not have to force myself.

So I've definitely changed my mind about this one. Definitely very handy when you're between a rock and a hard place.

 

[RClikeITS1999]

Absolutely!

 

[Pupung]

I am actually wondering if some place like clearnet leb site Ambeed.com would distribute this as it is totally uncontrolled.

They offer

$29.00/5g and https://www.ambeed.com/bretazenil.html​

which would be .0058 per dose.

Ambeed.com let me set up an account but I do not know if they wil sell to individuals without an LLC or a Corp. Ill email them now and get back to you.

Hi, did you find out about this?

 

[luckyrabbit]

I am actually wondering if some place like clearnet leb site Ambeed.com would distribute this as it is totally uncontrolled.

They offer

$29.00/5g and https://www.ambeed.com/bretazenil.html​

which would be .0058 per dose.

Ambeed.com let me set up an account but I do not know if they wil sell to individuals without an LLC or a Corp. Ill email them now and get back to you.

Also curious if they responded to your email.

 

[luckyrabbit]

So i emailed Ambeed, and they have a policy in which they only interact (and process purchase orders) for customers with a business email. I've been needing to make a website for something anyways, so once that's done I'll reach out to them again. If anybody else has a business email address or their own domain let me know what they say. I'd be down to throw in for at least 5g for my GC/MS experiment