I am a recent discoverer of these and have to say I am a big fan. Although I've found the line between the right dose, and too much to be a thin line, I still don't see them as dangerous as other PKs as far as OD goes.
The problems I could see would be things like the friend falling on her face and injuring herself story. This could also turn into stumbling into traffic, or into a subway train- not on purpose.
We all know, don't drink with press meds, blah, blah,…I drink with V all the time so I'm used to it, but I say if you do not have a tolerance for $oma, do not take more than two and drink. I stumbled and fell destroying my closet door after taking three over an entire night with 3 or 4 drinks. I never get like that.
Now a days I won't take more than two if I have to be in public. The stuff works better than PK for my back muscles tightness, the problem for me is I loose fine motor skills. My hands shake and I can't type. I need to type at work so I can't take 2 full ones at work.
If you are careful, and you want to take a half strip (or a full one for the serious and experienced vet only) do not leave the house, preferably the bed. The danger is not as much with OD as with injury. IMHO.
Our resident expert HighTIde has many great posts about the stuff on here, and knows way more than me.